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D8941

Sigma-Aldrich

2,6-Difluoro-4-[2-(phenylsul­fonyl­amino)­ethyl­thio]­phenoxy­acet­amide

≥98% (HPLC), solid

Synonym(e):

PEPA

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About This Item

Empirische Formel (Hill-System):
C16H16N2O4S2F2
CAS-Nummer:
141286-78-4
Molekulargewicht:
402.44
MDL-Nummer:
MFCD04974493
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24278571
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

solid

Lagerbedingungen

protect from light

Farbe

white

Löslichkeit

DMSO: >20 mg/mL

SMILES String

NC(=O)COc1c(F)cc(SCCNS(=O)(=O)c2ccccc2)cc1F

InChI

1S/C16H16F2N2O4S2/c17-13-8-11(9-14(18)16(13)24-10-15(19)21)25-7-6-20-26(22,23)12-4-2-1-3-5-12/h1-5,8-9,20H,6-7,10H2,(H2,19,21)

InChIKey

GTACSIONMHMRPD-UHFFFAOYSA-N

Angaben zum Gen

human ... GRIA1(2890) , GRIA2(2891) , GRIA3(2892) , GRIA4(2893)

Biochem./physiol. Wirkung

2,6-Difluoro-4-[2-(phenylsul­fonyl­amino)­ethyl­thio]­phenoxy­acet­amide is a structurally novel, selective, high affinity AMPA ionotropic glutamate receptor agonist that reduces ischemia-induced performance deficits in rats.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

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Neuroscience letters, 612, 126-131 (2015-12-08)
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Quan-Guang Zhang et al.
Hippocampus, 20(1), 65-77 (2009-03-31)
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) are responsible for excitotoxicity induced by ischemic injury in hippocampal CA1 neurons, whereas the molecular mechanisms responsible for their neurotrophic activities are much less studied. Here, we examined the neuroprotective effect of positive modeulation of AMPARs
Yanchao Xu et al.
Journal of colloid and interface science, 565, 23-34 (2020-01-14)
Nanofiltration (NF) membranes with tannic acid (TA) based selective layers have been intensively studied in recent years, but they still suffer from poor inorganic salt rejection. This study provided a first report on mussel-inspired co-deposition of TA and amine to
Mary L Huff et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(4), 861-873 (2014-09-27)
Recent findings suggest that the mesolimbic dopamine neurons, known to promote cocaine-seeking behavior, are strongly inhibited by a newly characterized region of the midbrain known as the rostromedial tegmental nucleus (RMTg). The RMTg appears to be involved in generating reward-prediction
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