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D7137

Sigma-Aldrich

Dihydroxyacetonphosphat Dilithiumsalz

≥93% dry basis (enzymatic)

Synonym(e):

1,3-Dihydroxy-2-propanon-1-phosphat Dilithiumsalz, 1-Hydroxy-3-(phosphonooxy)-2-propanon Dilithiumsalz, DHAP

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About This Item

Empirische Formel (Hill-System):
C3H5Li2O6P
CAS-Nummer:
102783-56-2
Molekulargewicht:
181.92
Beilstein:
1708891
MDL-Nummer:
MFCD00077731
UNSPSC-Code:
12352201
PubChem Substanz-ID:
24894082
NACRES:
NA.25

Biologische Quelle

bovine (casein)

Qualitätsniveau

200

Assay

≥93% dry basis (enzymatic)

Form

powder

Verunreinigungen

~0.2 mol % D-glyceraldehyde 3-phosphate

Farbe

white

Löslichkeit

soluble 50mg plus 1ml of H2O, clear, colorless to faintly yellow

Anionenspuren

phosphate (PO43-): ~5 mol %

Kationenspuren

Li: 5.5-8.0% (dry basis)

Lagertemp.

−20°C

SMILES String

[Li+].[Li+].OCC(=O)COP([O-])([O-])=O

InChI

1S/C3H7O6P.2Li/c4-1-3(5)2-9-10(6,7)8;;/h4H,1-2H2,(H2,6,7,8);;/q;2*+1/p-2

InChIKey

QWIKESRFRWLYIA-UHFFFAOYSA-L

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Anwendung

Dihydroxyacetone phosphate (DHAP) is used in fructose metabolism, triose and glycation research. It is used in studies involving the metabolism of three-carbon sugar pools and their roles in physiological and physical processes. DHAP may be used as a substrate to help identify, differentiate and characterize fructose-bisphosphate aldolase(s) (ALDOA) and triosephosphate isomerase(s). DHAP may be used to study cellular glycation stress.

Biochem./physiol. Wirkung

Dihydroxyacetone phosphate (DHAP) is a metabolic intermediate involved in many pathways, including glycolysis, gluconeogenesis, glycerol metabolism, phosphatidic acid synthesis, fat metabolism, and the Calvin cycle.

Vorsicht

Unlike the dimethyl ketal, does not require hydrolysis prior to use as a substrate.

Angaben zur Herstellung

Enzymatically prepared.

Sonstige Hinweise

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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M Merced Malabanan et al.
Journal of the American Chemical Society, 133(41), 16428-16431 (2011-09-24)
The L232A mutation in triosephosphate isomerase (TIM) from Trypanosoma brucei brucei results in a small 6-fold decrease in k(cat)/K(m) for the reversible enzyme-catalyzed isomerization of glyceraldehyde 3-phosphate to give dihydroxyacetone phosphate. In contrast, this mutation leads to a 17-fold increase
Hong-Yan Zhao et al.
BMC biotechnology, 18(1), 34-34 (2018-06-03)
Mesophilic alkaline serine proteases from various bacteria have been commercially applied in a range of industries owing to their high catalytic efficiency and wide substrate specificity. However, these proteases have an optimal catalytic temperature of approximately 50 °C, and their activity
Virginia De Cesare et al.
Cell chemical biology, 25(9), 1117-1127 (2018-07-19)
Due to their role in many diseases, enzymes of the ubiquitin system have recently become interesting drug targets. Despite efforts, primary screenings of compound libraries targeting E2 enzymes and E3 ligases have been strongly limited by the lack of robust
Valentina Piano et al.
Biochemical and biophysical research communications, 481(1-2), 51-58 (2016-11-12)
Although the precise functions of ether phospholipids are still poorly understood, significant alterations in their physiological levels are associated either to inherited disorders or to aggressive metastatic cancer. The essential precursor, alkyl-dihydroxyacetone phosphate (DHAP), for all ether phospholipids species is
Nasser M Al-Daghri et al.
Scientific reports, 7(1), 12633-12633 (2017-10-05)
Obesity is a pathological condition caused by genetic and environmental factors, including vitamin D deficiency, which increases the risk of developing cardiovascular disorders and diabetes. This case-control study was designed to verify whether serum profiles could be identified differentiating obese
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