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D3190

Sigma-Aldrich

Dithiobiuret

97%, solid

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About This Item

CAS-Nummer:
541-53-7
EG-Nummer:
208-784-8
MDL-Nummer:
MFCD00037832
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24893733
NACRES:
NA.77

Assay

97%

Form

solid

SMILES String

NC(=S)NC(N)=S

InChI

1S/C2H5N3S2/c3-1(6)5-2(4)7/h(H5,3,4,5,6,7)

InChIKey

JIRRNZWTWJGJCT-UHFFFAOYSA-N

Allgemeine Beschreibung

Paralytic agent.

Piktogramme

Skull and crossbones
GHS06

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral

Lagerklassenschlüssel

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Analysenzertifikate (COA)

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Z Sahenk
Acta neuropathologica, 81(2), 141-147 (1990-01-01)
It has been well established that 2,4-dithiobiuret (DTB) intoxication in rats produces a rapidly progressive hindlimb paralysis within days. The cause of this has, until recently, been explained on the basis of a physiological abnormality that involves a prejunctional impairment
J Rosenberg et al.
Molecular pharmacology, 33(6), 611-616 (1988-06-01)
Inhibition of in vitro translation activity by the chemotherapeutic agent cisplatin has been studied. Peptide synthesis was measured in translation assays prepared from guinea pig and rabbit reticulocyte lysates. There is a concentration- and time-dependent inactivation of translation by cisplatin.
J M Spitsbergen et al.
Toxicology and applied pharmacology, 102(1), 68-79 (1990-01-01)
Treatment of rats for 5 to 6 days with dithiobiuret (DTB, 1 mg/kg/day, ip) causes a flaccid, ascending neuromuscular weakness which is associated with a decreased end-plate potential (EPP) amplitude, quantal content, miniature end-plate potential (MEPP) frequency, and prolongation of
W D Atchison et al.
Experimental neurology, 85(1), 63-68 (1984-07-01)
Urinary excretion of porphyrin precursors delta-aminolevulinic acid (ALA) and porphobilinogen (PBG) and total porphyrins was measured during intoxication of rats with 2,4-dithiobiuret (DTB), a chemical which produces delayed-onset neuromuscular weakness, in an attempt to ascertain whether or not DTB poisoning
K D Williams et al.
Toxicology and applied pharmacology, 91(2), 212-221 (1987-11-01)
To evaluate the hypothesis that depressed neuromuscular transmission causes dithiobiuret (DTB)-induced muscle weakness in rats, the temporal development of impaired treadmill performance and deficits in the nerve-elicited muscle contractions were compared during daily treatment with the toxicant (DTB, 1 mg/kg/day
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