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D0444

DT-2 -trifluoracetat (Salz)

Name: DT-2 -trifluoracetat (Salz)
Brand: SIGMA

≥95% (HPLC), film

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise

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About This Item

Empirische Formel (Hill-System):

C₁₂₂H₂₂₃N₅₃O₂₃ · xC₂HF₃O₂

Molekulargewicht:

2800.42 (free base basis)

UNSPSC-Code:

12352200

NACRES:

NA.77

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Sigma-Aldrich

39286

Hydroxystilbamidin-bis(methansulfonat)

Qualitätsniveau

200

Assay

≥95% (HPLC)

Form

film

Zusammensetzung

Peptide content, ≥60%

Farbe

colorless to white

Löslichkeit

H₂O: 0.5 mg/mL, clear

Versandbedingung

wet ice

Lagertemp.

−20°C

Amino Acid Sequence

Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-Leu-Arg-Lys-Lys-Lys-Lys-Lys-His-NH2

Biochem./physiol. Wirkung

Cell permeable cGMP protein kinase (PKG) inhibitor

Leistungsmerkmale und Vorteile

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Highly specific, membrane-permeant peptide blockers of cGMP-dependent protein kinase Ialpha inhibit NO-induced cerebral dilation.

W R Dostmann et al.

Proceedings of the National Academy of Sciences of the United States of America, 97(26), 14772-14777 (2000-12-20)

Arrays of octameric peptide libraries on cellulose paper were screened by using (32)P-autophosphorylated cGMP-dependent protein kinase Ialpha (cGPK) to identify peptide sequences with high binding affinity for cGPK. Iterative deconvolution of every amino acid position in the peptides identified the

Inhibition of cGMP-dependent protein kinase by the cell-permeable peptide DT-2 reveals a novel mechanism of vasoregulation.

Mark S Taylor et al.

Molecular pharmacology, 65(5), 1111-1119 (2004-04-23)

Cyclic GMP-dependent protein kinase (PKG) serves as an important physiological regulator of vascular reactivity and tone. However, available inhibitors of PKG have exhibited variable effects in intact tissue, hindering the elucidation of the functional role of PKG in blood vessels.

Inhibition of cGMP-dependent protein kinase reduces the response to sonic hedgehog in neuralized embryoid bodies.

Christin Christensen et al.

Stem cells and development, 15(5), 647-654 (2006-11-16)

Previously, we have shown that increasing the intracellular cGMP concentration enhances the sonic hedgehog (Shh) response in neural plate cells. The use of two mouse embryonic stem (ES) cell lines allowed a highly sensitive and reproducible quantification of the Shh

Artikel

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