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C8977

Sigma-Aldrich

Monoclonal Anti-CREB antibody produced in rabbit

clone 48H2, purified immunoglobulin, buffered aqueous glycerol solution

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About This Item

MDL-Nummer:
MFCD01092316
UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

200

Konjugat

unconjugated

Antikörperform

purified immunoglobulin

Antikörper-Produkttyp

primary antibodies

Klon

48H2, monoclonal

Form

buffered aqueous glycerol solution

Mol-Gew.

antigen 43 kDa

Speziesreaktivität

rat, human, monkey, mouse

Methode(n)

ChIP: 1:50
flow cytometry: 1:400
immunocytochemistry: 1:800
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:6,400
immunohistochemistry (frozen sections): 1:6,400
immunoprecipitation (IP): 1:250
indirect immunofluorescence: 1:800
western blot: 1:1,000 using extracts from SK-N-MC cells treated with forskolin or FGF

Isotyp

IgG

UniProt-Hinterlegungsnummer

P16220

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... CREB1(1385)
mouse ... Creb1(12912)
rat ... Creb1(81646)

Spezifität

Detects endogenous levels of total CREB protein.

Immunogen

Recombinant protein specific to amino terminus of human CREB.

Physikalische Form

Solution in 10 mM sodium HEPES, pH 7.5, containing 150 mM sodium chloride, 100 μg/mL bovine serum albumin, and < 0.02% sodium azide with 50% glycerol.

Rechtliche Hinweise

Rabbit monoclonals produced using Epitomics® Technology, U.S.Patent No. 5,675,063.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
SLBS7049
SLBR4032V
SLBL2579V
SLBH7860V
SLBH7860

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Die Dokumentenbibliothek aufrufen

Min Gyu Lee et al.
The Journal of biological chemistry, 278(42), 41047-41058 (2003-08-02)
A common signature of many cancers is a high glucose catabolic rate frequently dependent on the overexpression of Type II hexokinase (HKII), a mitochondrial bound enzyme that also suppresses cell death. As the tumor HKII promoter plays a significant role
CREB: a mediator of long-term memory from mollusks to mammals.
D A Frank et al.
Cell, 79(1), 5-8 (1994-10-07)
J C Yin et al.
Cell, 81(1), 107-115 (1995-04-07)
Genetic studies of memory formation in Drosophila have revealed that the formation of a protein synthesis-dependent long-term memory (LTM) requires multiple training sessions. LTM is blocked specifically by induced expression of a repressor isoform of the cAMP-responsive element-binding protein (CREB).
G A Gonzalez et al.
Cell, 59(4), 675-680 (1989-11-17)
In this paper, we demonstrate that phosphorylation of CREB at Ser-133 is induced 6-fold in vivo, following treatment of PC12 cells with forskolin. By contrast, no such induction was observed in the kinase A-deficient PC12 line A126-1B2 (A126). Using F9
R P Kwok et al.
Nature, 370(6486), 223-226 (1994-07-21)
The transcription factor CREB binds to a DNA element known as the cAMP-regulated enhancer (CRE). CREB is activated through phosphorylation by protein kinase A (PKA), but precisely how phosphorylation stimulates CREB function is unknown. One model is that phosphorylation may
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