C6348

Monoclonal Anti-CXCR2 (IL-8 RB) antibody produced in mouse

clone 48311.211, purified immunoglobulin, lyophilized powder

• MDL-Nummer: MFCD01864633
• UNSPSC-Code: 51111800
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 100
• Konjugat: unconjugated
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: 48311.211, monoclonal
• Form: lyophilized powder
• Speziesreaktivität: human
• Methode(n): flow cytometry: suitable; neutralization: suitable
• Isotyp: IgG2a
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... IL8RB(3579) ; mouse ... Il8rb(12765)

Beschreibung

Allgemeine Beschreibung

The antibody will neutralize human cell surface CXCR-2 mediated-myloperoxidase release from human granulocytes induced by GROα. It will not block myeloperoxidase release induced by IL-8. The antibody reacts with human CXCR-2 transfectant cells and not the parent cell line. The antibody shows no cross-reactivity with CXCR-1.

Immunogen

human CXCR2 transfected NSO mouse myeloma cells.

Biochem./physiol. Wirkung

CXCR2 is a G protein-coupled receptor that binds IL-8 with high affinity. It mediates migration of neutrophils to the sites of inflammation. It also binds CXCL1 and stimulates growth of melanomas.

Physikalische Form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Angaben zur Herstellung

Purified using protein G.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)