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C6240

Sigma-Aldrich

CITCO

≥98% (HPLC), solid

Synonym(e):

6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime

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About This Item

Empirische Formel (Hill-System):
C19H12N3OCl3S
CAS-Nummer:
338404-52-7
Molekulargewicht:
436.74
MDL-Nummer:
MFCD00139608
UNSPSC-Code:
12352203
PubChem Substanz-ID:
24724448
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

solid

Lagerbedingungen

desiccated

Löslichkeit

DMSO: soluble 28 mg/mL
H2O: insoluble

Lagertemp.

−20°C

SMILES String

Clc1ccc(cc1)-c2nc3sccn3c2\C=N\OCc4ccc(Cl)c(Cl)c4

InChI

1S/C19H12Cl3N3OS/c20-14-4-2-13(3-5-14)18-17(25-7-8-27-19(25)24-18)10-23-26-11-12-1-6-15(21)16(22)9-12/h1-10H,11H2/b23-10+

InChIKey

ZQWBOKJVVYNKTL-AUEPDCJTSA-N

Allgemeine Beschreibung

CITCO is an imidazothiazole derivative. It stimulates human constitutive androstane receptor (CAR) nuclear translocation.

Anwendung

CITCO has been used for the activation of mouse constitutive androstane receptor (CAR) and human CAR.

Biochem./physiol. Wirkung

CITCO is a constitutive androstane receptor (CAR) agonist; nuclear receptor NR113 agonist.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

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Tadeja Režen et al.
Drug metabolism and disposition: the biological fate of chemicals, 45(8), 974-976 (2017-05-26)
Statins are well known lipid lowering agents that inhibit the enzyme 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase. They also activate drug metabolism but their exact receptor-mediated action has not been proven so far. We tested whether atorvastatin and rosuvastatin are direct ligands of
Susanne Johansson et al.
Clinical pharmacology in drug development, 6(5), 466-475 (2017-03-17)
Tenapanor (RDX5791, AZD1722) is an inhibitor of sodium/hydrogen exchanger isoform 3 in development for the treatment of constipation-predominant irritable bowel syndrome and the treatment of hyperphosphatemia in patients with chronic kidney disease on dialysis. We aimed to investigate whether tenapanor
Constitutive androstane receptor agonist CITCO inhibits growth and expansion of brain tumour stem cells
Chakraborty S , et al.
British Journal of Cancer, 104(3), 448-448 (2011)
Constitutive androstane receptor (Car)-driven regeneration protects liver from failure following tissue loss
Tschuor C, et l.
Journal of Hepatology, 65(1), 66-74 (2016)
Congrong Niu et al.
Frontiers in pharmacology, 11, 620197-620197 (2021-02-09)
The induction potentials of ligand-activated nuclear receptors on metabolizing enzyme genes are routinely tested for new chemical entities. However, regulations of drug transporter genes by the nuclear receptor ligands are underappreciated, especially in differentiated human hepatocyte cultures. In this study
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