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C130

Sigma-Aldrich

Chloro-APB hydrobromide

solid

Synonym(e):

(±)-6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide, (±)-SKF-82958 hydrobromide, 6-Chloro-N-allyl-SKF-38393 hydrobromide

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About This Item

Empirische Formel (Hill-System):
C19H20ClNO2 · HBr
CAS-Nummer:
80751-65-1
Molekulargewicht:
410.73
MDL-Nummer:
MFCD00069235
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24277890
NACRES:
NA.77

Form

solid

Farbe

tan

Löslichkeit

H2O: 3.7 mg/mL
aqueous base: unstable
ethanol: soluble

Lagertemp.

2-8°C

SMILES String

Br.Oc1cc2C(CN(CCc2c(Cl)c1O)CC=C)c3ccccc3

InChI

1S/C19H20ClNO2.BrH/c1-2-9-21-10-8-14-15(11-17(22)19(23)18(14)20)16(12-21)13-6-4-3-5-7-13;/h2-7,11,16,22-23H,1,8-10,12H2;1H

InChIKey

WLXGFAVTAAQOFH-UHFFFAOYSA-N

Angaben zum Gen

human ... DRD1(1812)

Anwendung

Chloro-APB hydrobromide has been used to pharmacologically stimulate D1 dopamine receptors and study its influence on locomotor response in fat mass and obesity-associated protein (FTO) deficient dopamine D1 receptor-expressing medium spiny neurons (D1 MSNs) of mice.

Biochem./physiol. Wirkung

Chloro-APB hydrobromide, also known as SKF 82958, is a D1 dopamine receptor agonist. D1 receptor agonists prevent and reverse fentanyl-induced respiratory depression, without impairing opioid analgesia, in cats.

Vorsicht

Light sensitive

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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Sigma-Aldrich

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