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A9789

Sigma-Aldrich

Anisomycin

from Streptomyces griseolus, ≥98% (HPLC), solid, protein synthesis inhibitor

Synonym(e):

(2R,3S,4S)-2-(4-Methoxybenzyl)-3,4-pyrrolidindiol-3-acetat, Flagecidin

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About This Item

Empirische Formel (Hill-System):
C14H19NO4
CAS-Nummer:
22862-76-6
Molekulargewicht:
265.30
Beilstein:
20705
EG-Nummer:
245-269-7
MDL-Nummer:
MFCD00077650
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24891496
NACRES:
NA.77

Produktbezeichnung

Anisomycin aus Streptomyces griseolus, ≥98% (HPLC), solid

Qualitätsniveau

300

Assay

≥98% (HPLC)

Form

solid

Farbe

white to faint yellow

Löslichkeit

H2O: 2 mg/mL (Aqueous solutions are stable over a wide range of pH at room temperature.)
DMSO: 20 mg/mL
methanol: 20 mg/mL

Wirkungsspektrum von Antibiotika

neoplastics

Wirkungsweise

protein synthesis | interferes

Lagertemp.

2-8°C

SMILES String

COc1ccc(C[C@H]2NC[C@H](O)[C@H]2OC(C)=O)cc1

InChI

1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6,12-15,17H,7-8H2,1-2H3/t12-,13+,14+/m1/s1

InChIKey

YKJYKKNCCRKFSL-RDBSUJKOSA-N

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Verwandte Kategorien

Biochem./physiol. Wirkung

Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. Reported to induce apoptosis in a variety of cells including promyelocytic leukemia cells, Jurkat cells, ventricular myocytes, and colon adenocarcinoma cells. Initiates intracellular signals and immediate early gene induction. Selective signaling agonist. Potent Jun-NH2 terminal kinase (JNK) agonist. Activates mitogen-activated protein (MAP) kinases (JNK/SAPK and p38/RK). Antiprotozoal agent.

Vorsicht

Hygroscopic

Piktogramme

Skull and crossbones
GHS06

Signalwort

Danger

H-Sätze

H301

Gefahreneinstufungen

Acute Tox. 3 Oral

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
119M4011V
14190405
049M4009V
039M4126V
14180912

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Sovan Sarkar et al.
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The target of rapamycin proteins regulate various cellular processes including autophagy, which may play a protective role in certain neurodegenerative and infectious diseases. Here we show that a primary small-molecule screen in yeast yields novel small-molecule modulators of mammalian autophagy.
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Parasitic infections are a major source of human suffering, mortality, and economic loss, but drug development for these diseases has been stymied by the significant expense involved in bringing a drug though clinical trials and to market. Identification of single
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