Direkt zum Inhalt
Merck
Alle Fotos(1)

Key Documents

View All Documentation

A8016

Sigma-Aldrich

Adenosin 5′-[β-thio]diphosphat Trilithiumsalz

≥80% (HPLC)

Synonym(e):

ADP-β-S, Adenosin-5′-0-(2-thiodiphosphat) Trilithiumsalz, Ado-5′-PP[S]

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise
Alle Fotos(1)

About This Item

Empirische Formel (Hill-System):
C10H12Li3N5O9P2S
CAS-Nummer:
73536-95-5
Molekulargewicht:
461.07
MDL-Nummer:
MFCD00077314
UNSPSC-Code:
41106305
eCl@ss:
32160414
PubChem Substanz-ID:
24891307
NACRES:
NA.77

Assay

≥80% (HPLC)

Form

powder

Lagertemp.

−20°C

SMILES String

[Li+].[Li+].[Li+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP([O-])(=O)OP([O-])([O-])=S)[C@@H](O)[C@H]3O

InChI

1S/C10H15N5O9P2S.3Li/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(23-10)1-22-25(18,19)24-26(20,21)27;;;/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H2,20,21,27);;;/q;3*+1/p-3/t4-,6-,7-,10-;;;/m1.../s1

InChIKey

CPKFUAYUUSSFFZ-MSQVLRTGSA-K

Suchen Sie nach ähnlichen Produkten? Aufrufen Leitfaden zum Produktvergleich

Verwandte Kategorien

Anwendung

Adenosine 5′-[β-thio]diphosphate is a substrate and inhibitor for AMP dependent enzyme systems. Adenosine 5′-[β-thio]diphosphate has been used to explore the myenteric control mechanisms of human esophageal motility and the effect of nitrergic and nonnitrergic neurotransmitters.
Adenosine 5′-[β-thio]diphosphate trilithium salt has been used to induce neuropathic pain in rats to study the effect of dorsal horn cannabinoid CB2 receptor activation on the expression of P2Y12 and P2Y13 (purinoceptors) receptors.

Biochem./physiol. Wirkung

P2Y receptor agonist.

Leistungsmerkmale und Vorteile

This compound is featured on the P2 Receptors: P2Y G-Protein Family page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sonstige Hinweise

Non-hydrolyzable ADP analog

Substrate

Substrate and inhibitor for AMP dependent enzyme systems.

Piktogramme

Health hazardExclamation mark
GHS08,GHS07

Signalwort

Warning

H-Sätze

H302,H371

Gefahreneinstufungen

Acute Tox. 4 Oral - STOT SE 2

Zielorgane

Eyes,Central nervous system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Activation of dorsal horn cannabinoid CB2 receptor suppresses the expression of P2Y 12 and P2Y 13 receptors in neuropathic pain rats
Niu J, et al.
Journal of Neuroinflammation, 14(1), 185-185 (2017)
Tibor Kiss
The European journal of neuroscience, 21(8), 2177-2185 (2005-05-05)
Members of the mytilus inhibitory peptide (MIP) family play an important role in the modulation of many physiological processes in molluscs. The signal transduction pathways affected by the MIP effect have not, however, been elucidated. Application of guanosine 5'-[gamma-thio]triphosphate tetralithium
Alexander K Filippov et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 26(36), 9340-9348 (2006-09-08)
We have shown previously that stimulation of heterologously expressed P2Y1 nucleotide receptors inhibits M-type K+ currents in sympathetic neurons. We now report that activation of endogenous P2Y1 receptors induces inhibition of the M-current in rat CA1/CA3 hippocampal pyramidal cells in
B Lecea et al.
American journal of physiology. Gastrointestinal and liver physiology, 300(5), G782-G794 (2011-02-19)
The aim of this study was to explore the myenteric mechanisms of control of human esophageal motility and the effect of nitrergic and nonnitrergic neurotransmitters. Human circular esophageal strips were studied in organ baths and with microelectrodes. Responses following electrical
R Rodríguez-Rodríguez et al.
British journal of pharmacology, 158(6), 1609-1620 (2009-10-23)
Extracellular nucleotides play a crucial role in the regulation of vascular tone and blood flow. Stimulation of endothelial cell P2Y1 receptors evokes concentration-dependent full dilatation of resistance arteries. However, this GPCR can desensitize upon prolonged exposure to the agonist. Our
Alle zugehörigen Dokumente anzeigen

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung.