A4142

Azaserin

≥98% (TLC)

• Synonym(e): O-Diazoacetyl-L-serin
• Empirische Formel (Hill-System): C₅H₇N₃O₄
• CAS-Nummer: 115-02-6
• Molekulargewicht: 173.13
• Beilstein: 1726602
• EG-Nummer: 204-061-6
• MDL-Nummer: MFCD00036802
• UNSPSC-Code: 12352209
• PubChem Substanz-ID: 24890830
• NACRES: NA.26

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (TLC)
• Form: powder
• Farbe: off-white to yellow-green
• Wirkungsspektrum von Antibiotika: fungi
• Wirkungsweise: enzyme | inhibits
• Lagertemp.: −20°C
• SMILES String: N[C@@H](COC(=O)C=[N+]=[N-])C(O)=O
• InChI: 1S/C5H7N3O4/c6-3(5(10)11)2-12-4(9)1-8-7/h1,3H,2,6H2,(H,10,11)/t3-/m0/s1
• InChIKey: MZZGOOYMKKIOOX-VKHMYHEASA-N

Beschreibung

Allgemeine Beschreibung

Chemical structure: amino acid derivatives

Anwendung

Used in cell culture for the selection of HGPRT revertants.

Biochem./physiol. Wirkung

Azaserine is an antibiotic and antifungal; it may also act as a tumor inducer. It is a structural analog of glutamine and competes with glutamine in binding to enzymes involved in purine biosynthesis. Azaserine inhibits purine biosynthesis by covalently reacting with cysteine residues in the enzyme active sites, such as in formylglycinamide ribonucleotide amidotransferase and PRPP amidotransferase. Azaserine can induce DNA damage via the formation of carboxymethylated bases and O⁶-methylguanine. Secretion of exo-1,3-β-glucanase and germ-tube formation of Candida albicans were inhibited by azaserine.

Sicherheitshinweise

• Piktogramme: GHS06,GHS08
• Signalwort: Danger
• H-Sätze: H301,H351
• P-Sätze: P201 - P301 + P310 + P330
• Gefahreneinstufungen: Acute Tox. 3 Oral - Carc. 2
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges