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A2731

Sigma-Aldrich

AMG 9810

≥98% (HPLC), powder

Synonym(e):

2E-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-dimethylethyl)phenyl]-2-Propenamide

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About This Item

Empirische Formel (Hill-System):
C21H23NO3
CAS-Nummer:
545395-94-6
Molekulargewicht:
337.41
MDL-Nummer:
MFCD00955103
UNSPSC-Code:
12352203
PubChem Substanz-ID:
329770793
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

powder

Farbe

white to beige

Löslichkeit

DMSO: >5 mg/mL

Ersteller

Amgen

Lagertemp.

2-8°C

SMILES String

CC(C)(C)c1ccc(\C=C\C(=O)Nc2ccc3OCCOc3c2)cc1

InChI

1S/C21H23NO3/c1-21(2,3)16-7-4-15(5-8-16)6-11-20(23)22-17-9-10-18-19(14-17)25-13-12-24-18/h4-11,14H,12-13H2,1-3H3,(H,22,23)/b11-6+

InChIKey

GZTFUVZVLYUPRG-IZZDOVSWSA-N

Biochem./physiol. Wirkung

AMG 9810 is the cinnamide TRPV1 (vanilloid receptor 1) antagonist, that can prevent eye wiping behavior, stimulated by capsaicin and can inverse hyperalgesia in an animal model of inflammatory pain. It possesses antihyperalgesic properties.
AMG 9810 is a potent, non-vanilloid, antagonist of the TRPV1 receptor. IC50 = 17 nM.

Leistungsmerkmale und Vorteile

This compound was developed by Amgen. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H302,H413

Gefahreneinstufungen

Acute Tox. 4 Oral - Aquatic Chronic 4

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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GSK1016790A ≥98% (HPLC)

Sigma-Aldrich

G0798

GSK1016790A

BAPTA-AM ≥95% (HPLC)

Sigma-Aldrich

A1076

BAPTA-AM

GW9662 >98% (HPLC)

Sigma-Aldrich

M6191

GW9662

Capsaicin ≥95%, from Capsicum sp.

Sigma-Aldrich

M2028

Capsaicin

Mohammad Zakir Hossain et al.
International journal of molecular sciences, 19(12) (2018-12-21)
The larynx and associated laryngopharyngeal regions are innervated by the superior laryngeal nerve (SLN) and are highly reflexogenic. Transient receptor potential (TRP) channels have recently been detected in SLN innervated regions; however, their involvement in the swallowing reflex has not
Michele Hummel et al.
World journal of gastroenterology, 23(33), 6065-6076 (2017-10-04)
To evaluate whether non-steroidal anti-inflammatory drugs (NSAIDs)-induced gastropathy is a clinically predictive model of referred visceral hypersensitivity. Gastric ulcer pain was induced by the oral administration of indomethacin to male, CD1 mice ( Results showed that two opioids and a
Mark H Pitcher et al.
Molecular pain, 3, 17-17 (2007-07-03)
The Na+, K+, 2Cl- type I cotransporter (NKCC1) and TRPV1 receptors, at the level of the dorsal horn, have been implicated in mediating allodynia in response to an inflammatory insult. The NKCC1 cotransporter regulates intracellular [Cl-] and thus the magnitude
Elham Hakimizadeh et al.
Iranian journal of basic medical sciences, 15(3), 795-802 (2013-03-16)
Fatty acid is amide hydrolase which reduce endogenous anandamide. Transient receptor potential vanilloid-1 (TRPV1) channels have been reported to have a role in the modulation of anxiety-like behaviors in rodents. In the present study, the effects of either endocannabinoid system
Éva Borbély et al.
Frontiers in pharmacology, 11, 594479-594479 (2021-02-02)
The tachykinin hemokinin-1 (HK-1) is involved in immune cell development and inflammation, but little is known about its function in pain. It acts through the NK1 tachykinin receptor, but several effects are mediated by a yet unidentified target. Therefore, we
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