A2169

3′-Azido-3′-Desoxythymidin

≥98% (HPLC), powder, reverse transcriptase inhibitor

• Synonym(e): AZT, Azidothymidin, ZDV, Zidovudin
• Empirische Formel (Hill-System): C₁₀H₁₃N₅O₄
• CAS-Nummer: 30516-87-1
• Molekulargewicht: 267.24
• Beilstein: 3595791
• MDL-Nummer: MFCD00006536
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278143
• NACRES: NA.77

Eigenschaften

• Produktbezeichnung: 3′-Azido-3′-Desoxythymidin, ≥98% (HPLC)
• Assay: ≥98% (HPLC)
• Form: powder
• mp (Schmelzpunkt): 113-115 °C (lit.)
• Löslichkeit: H₂O: 50 mg/mL
• Lagertemp.: −20°C
• SMILES String: CC1=CN([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)C(=O)NC1=O
• InChI: 1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1
• InChIKey: HBOMLICNUCNMMY-XLPZGREQSA-N
• Angaben zum Gen: human ... HIVE1(3095) ; mouse ... Slc29a1(63959)

Beschreibung

Anwendung

3′-Azido-3′-deoxythymidine has been used as the reverse transcriptase inhibitor to inhibit the viral genome integration and as an antimicrobial agent to evaluate its anti-Salmonella activity.

Biochem./physiol. Wirkung

Umkehrtranscriptase-Inhibitor aktiv gegen HIV-1-Viren

Azidothymidine (AZT), a thymidine analogue, is a reverse transcriptase inhibitor against the HIV-1 virus. Azidothymidine has been shown to decrease CRISPR-mediated homology-directed repair (HDR) efficiency.

Leistungsmerkmale und Vorteile

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Sicherheitshinweise

• Piktogramme: GHS08
• Signalwort: Warning
• H-Sätze: H341,H351
• P-Sätze: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Gefahreneinstufungen: Carc. 2 - Muta. 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges