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74480

Sigma-Aldrich

L-Norepinephrin -hydrochlorid

≥98.0% (sum of enantiomers, HPLC)

Synonym(e):

L-Arterenol -hydrochlorid, L-Noradrenalin -hydrochlorid

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About This Item

Empirische Formel (Hill-System):
C8H11NO3 · HCl
CAS-Nummer:
329-56-6
Molekulargewicht:
205.64
Beilstein:
3916100
EG-Nummer:
206-345-5
MDL-Nummer:
MFCD00064560
UNSPSC-Code:
12352209
PubChem Substanz-ID:
57652452
NACRES:
NA.77

Assay

≥98.0% (sum of enantiomers, HPLC)

Form

crystals

Optische Aktivität

[α]20/D −38.5±5°, c = 2% in H2O

mp (Schmelzpunkt)

~150 °C (dec.)

Lagertemp.

2-8°C

SMILES String

Cl[H].NC[C@H](O)c1ccc(O)c(O)c1

InChI

1S/C8H11NO3.ClH/c9-4-8(12)5-1-2-6(10)7(11)3-5;/h1-3,8,10-12H,4,9H2;1H/t8-;/m0./s1

InChIKey

FQTFHMSZCSUVEU-QRPNPIFTSA-N

Angaben zum Gen

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152) , ADRB1(153) , ADRB2(154) , ADRB3(155)

Biochem./physiol. Wirkung

Adrenal medullary stress hormone, mediator of the fight-or-flight response; and the primary neurotransmitter in the post-ganglionic sympathetic (adrenergic) nervous system.

Piktogramme

Skull and crossbones
GHS06

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral

Lagerklassenschlüssel

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Analysenzertifikate (COA)

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Anyue Yin et al.
British journal of pharmacology, 175(16), 3394-3406 (2018-06-03)
Development of combination therapies has received significant interest in recent years. Previously, a two-receptor one-transducer (2R-1T) model was proposed to characterize drug interactions with two receptors that lead to the same phenotypic response through a common transducer pathway. We applied
Giovanni D'Andrea et al.
Scientific reports, 9(1), 6151-6151 (2019-04-18)
Early diagnosis of Parkinson's disease (PD) remains a challenge to date. New evidence highlights the potential clinical value of circulating trace amines (TAs) in early-stage PD and their involvement in disease progression. A new ultra performance chromatography mass spectrometry (UPLC-MS/MS)
Jian Wen et al.
The Laryngoscope, 124(5), E188-E193 (2013-10-12)
Noise generated by instruments, such as mastoid or craniotomy drills, may cause hearing damage by reducing the cochlear blood flow (CoBF). This study investigated whether dexmedetomidine can lessen noise-induced hearing loss (NIHL) in a guinea pig model. Animal study using
Wataru Inoue et al.
Nature neuroscience, 16(5), 605-612 (2013-04-09)
Exposure to a stressor sensitizes behavioral and hormonal responses to future stressors. Stress-associated release of noradrenaline enhances the capacity of central synapses to show plasticity (metaplasticity). We found noradrenaline-dependent metaplasticity at GABA synapses in the paraventricular nucleus of the hypothalamus
Sébastien Zanella et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(1), 36-50 (2014-01-02)
Neuronal networks are endogenously modulated by aminergic and peptidergic substances. These modulatory processes are critical for maintaining normal activity and adapting networks to changes in metabolic, behavioral, and environmental conditions. However, disturbances in neuromodulation have also been associated with pathologies.
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