241R-4

Cyclin D1 (EP12) Rabbit Monoclonal Primary Antibody

• UNSPSC-Code: 12352200
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100; 500
• Konjugat: unconjugated
• Antikörperform: culture supernatant
• Antikörper-Produkttyp: primary antibodies
• Klon: EP12, monoclonal
• Beschreibung: For In Vitro Diagnostic Use in Select Regions (See Chart)
• Form: buffered aqueous solution
• Speziesreaktivität: human
• Verpackung: vial of 0.1 mL concentrate (241R-44); vial of 0.5 mL concentrate (241R-45); bottle of 1.0 mL predilute (241R-47); vial of 1 mL concentrate (241R-46); bottle of 7.0 mL predilute (241R-48)
• Hersteller/Markenname: Cell Marque^™
• Methode(n): immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
• dilution: 1:100-1:500
• Isotyp: IgG
• Kontrolle: mantle cell lymphoma
• Versandbedingung: wet ice
• Lagertemp.: 2-8°C
• Visualisierung: nuclear
• Angaben zum Gen: human ... CCND1(595)

Beschreibung

Allgemeine Beschreibung

Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. Cyclins are proteins that govern transitions through distinct phases of the cell cycle by regulating the activity of the cyclin-dependent kinases. In mid-to-late G1 phase of the cell cycle, cyclin D1 shows a maximum expression following growth factor stimulation. Anti-cyclin D1 has been successfully employed and is a promising tool for further studies in both cell cycle biology and cancer associated abnormalities. This antibody is useful for separating mantle cell lymphomas (cyclin D1 positive) from chronic lymphocytic leukemia/small lymphocytic lymphoma and follicular lymphomas (cyclin D1 negative). Hairy cell leukemia and plasma cell myeloma can weakly express Cyclin D1.

Qualität

IVD

IVD

IVD

RUO

Verlinkung

Cyclin D1 Positive Control Slides, Product No. 241S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physikalische Form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Angaben zur Herstellung

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Sonstige Hinweise

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Rechtliche Hinweise

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable