S0883

Sulfasalazin

97.0-101.5%

• Synonym(e): 2-Hydroxy-5-{{4-[(2-pyridinylamino)-sulfonyl]-phenyl}-azo}-benzoesäure, 5-[4-(2-Pyridylsulfamoyl)-phenylazo]-salicylsäure, Salicylazosulfapyridin
• Empirische Formel (Hill-System): C₁₈H₁₄N₄O₅S
• CAS-Nummer: 599-79-1
• Molekulargewicht: 398.39
• Beilstein: 356241
• EG-Nummer: 209-974-3
• MDL-Nummer: MFCD00057363
• UNSPSC-Code: 41116107
• PubChem Substanz-ID: 329824182
• NACRES: NA.24

Eigenschaften

• Qualitätsniveau: 200
• Assay: 97.0-101.5%
• Form: powder
• Methode(n): HPLC: suitable; gas chromatography (GC): suitable
• mp (Schmelzpunkt): 260-265 °C (dec.) (lit.)
• Anwendung(en): forensics and toxicology; pharmaceutical (small molecule)
• Wirkungsweise: DNA synthesis | interferes; enzyme | inhibits
• SMILES String: OC(=O)c1cc(ccc1O)\N=N\c2ccc(cc2)S(=O)(=O)Nc3ccccn3
• InChI: 1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)/b21-20+
• InChIKey: NCEXYHBECQHGNR-QZQOTICOSA-N
• Angaben zum Gen: human ... ALOX5(240) , PTGS1(5742) , PTGS2(5743)

Beschreibung

Allgemeine Beschreibung

Chemical structure: sulfonamide

Sulfasalazine (SSZ) belongs to the sulfonamide class of drugs, which can be metabolized into 5-aminosalicylic acid and sulfapyridine. SSZ is obtained as a reaction product of an antibacterial agent (sulfapyridine) and an anti-inflammatory agent (salicylic acid).

Anwendung

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Sulfasalazine has been used as an analytical standard in clinical studies:

• For investigating its therapeutic potential in patients suffering from multiple sclerosis (MS).
• For studying its role as an antiarthritic agent via inhibition of the cartilage degeneration and pain associated with progression of osteoarthritis in the rat, which is used as the test animal.

It may also be used as an analytical reference standard for the quantification of the analyte in biological samples and aqueous samples using enzyme-linked immunosorbent assay (ELISA) and spectrofluorimetic technique.

Sicherheitshinweise

• Piktogramme: GHS08,GHS09
• Signalwort: Danger
• H-Sätze: H317,H334,H351,H361f,H411
• P-Sätze: P202 - P261 - P273 - P280 - P302 + P352 - P308 + P313
• Gefahreneinstufungen: Aquatic Chronic 2 - Carc. 2 - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Faceshields, Gloves