PHR1834

Itraconazol

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(e): Itraconazol, Oriconazol, R51211, Sporanox
• Empirische Formel (Hill-System): C₃₅H₃₈Cl₂N₈O₄
• CAS-Nummer: 84625-61-6
• Molekulargewicht: 705.63
• MDL-Nummer: MFCD00870168
• UNSPSC-Code: 41116107
• PubChem Substanz-ID: 329823629
• NACRES: NA.24

Eigenschaften

• Qualität: certified reference material; pharmaceutical secondary standard
• Qualitätsniveau: 300
• Agentur: traceable to Ph. Eur. I7000000; traceable to USP 1354251
• API-Familie: itraconazole
• Analysenzertifikat (CofA): current certificate can be downloaded
• Verpackung: pkg of 200 mg
• Methode(n): HPLC: suitable; gas chromatography (GC): suitable
• Anwendung(en): pharmaceutical (small molecule)
• Format: neat
• Lagertemp.: 2-30°C
• SMILES String: CCC(C)N1N=CN(C1=O)c2ccc(cc2)N3CCN(CC3)c4ccc(OCC5COC(Cn6cncn6)(O5)c7ccc(Cl)cc7Cl)cc4
• InChI: 1S/C35H38Cl2N8O4/c1-3-25(2)45-34(46)44(24-40-45)29-7-5-27(6-8-29)41-14-16-42(17-15-41)28-9-11-30(12-10-28)47-19-31-20-48-35(49-31,21-43-23-38-22-39-43)32-13-4-26(36)18-33(32)37/h4-13,18,22-25,31H,3,14-17,19-21H2,1-2H3
• InChIKey: VHVPQPYKVGDNFY-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Anwendung

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem./physiol. Wirkung

Itraconazol hemmt Cytochrom-P-450-abhängige Enzyme, was zur Inhibition der Ergosterol-Synthese führt. Das geschieht durch Interaktion mit 14-α-Demethylase, einem Cytochrom-P-450-Enzym, das für die Umwandlung von Lanosterol in Ergosterol benötigt wird. Ergosterol ist ein entscheidender Bestandteil pilzlicher Zellmembranen. Deshalb führt seine Hemmung zu erhöhter Zelldurchlässigkeit, sodass Zellinhalte austreten können. Itraconazol kann auch die endogene Atmung hemmen, mit Membran-Phospholipiden interagieren, die Umwandlung von Hefen in Mycelformen hemmen, die Purin-Aufnahme hemmen und die Biosynthese von Triglyceriden und Phospholipiden beeinträchtigen.

Hinweis zur Analyse

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Sonstige Hinweise

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Fußnote

To see an example of a Certificate of Analysis for this material enter LRAC0395 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302,H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable