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Merck

PHR1309

Supelco

Dimethyl Sulfoxide

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(e):

DMSO

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About This Item

CAS-Nummer:
EG-Nummer:
UNSPSC-Code:
41116107
NACRES:
NA.24

Qualität

certified reference material
pharmaceutical secondary standard

Qualitätsniveau

Agentur

traceable to Ph. Eur. D2050000
traceable to USP 1211006

Analysenzertifikat (CofA)

current certificate can be downloaded

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

2-8°C

InChI

1S/C2H6OS/c1-4(2)3/h1-2H3

InChIKey

IAZDPXIOMUYVGZ-UHFFFAOYSA-N

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Allgemeine Beschreibung

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards.
Dimethyl Sulfoxide (DMSO) is an amphipathic molecule and contains both highly polar and apolar groups, making it an efficient solvent as it can dissolve in both aqueous and organic solvents. It has its therapeutic use in the treatment of a variety of human conditions such as brain edema, amyloidosis, interstitial cystitis, and schizophrenia. It is a commonly used solvent for hydrophobic pharmaceutical agents, exhibiting effective hydroxyl radical scavenging ability. Commercially it is produced by oxidation of dimethylsulfide (DMS) with dinitrogen tetroxide. It is a component of a wide variety of foodstuffs and beverages.

Anwendung

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Hinweis zur Analyse

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Sonstige Hinweise

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Fußnote

To see an example of a Certificate of Analysis for this material enter LRAA0526 in the slot below. This is an example certificate only and may not be the lot that you receive.

Empfohlene Produkte

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

188.6 °F - closed cup

Flammpunkt (°C)

87 °C - closed cup


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Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Application of nuclear magnetic resonance spectroscopy for quantitative analysis of miconazole, metronidazole and sulfamethoxazole in pharmaceutical and urine samples
Salem AA, et al.
Journal of Pharmaceutical and Biomedical Analysis, 41(2), 654-661 (2006)
Room temperature ionic liquid as matrix medium for the determination of residual solvents in pharmaceuticals by static headspace gas chromatography
Liu F and Jiang Y
Journal of Chromatography A, 1167(1), 116-119 (2007)
Solvation and ion pairing of alkali-metal alkoxides in dimethyl sulfoxide. Conductometric studies
Exner JH and Steiner EC
Journal of the American Chemical Society, 96(6), 1782-1787 (1974)
A rapid permethylation of glycolipid, and polysaccharide catalyzed by methylsulfinyl carbanion in dimethyl sulfoxide
HAKOMORI S
Journal of Biochemistry, 55(2), 205-208 (1964)
Protective effects of the free radical scavengers, dimethyl sulfoxide and ethanol, in cerebral ischemia in gerbils
Phillis JW, et al.
Neuroscience Letters, 244(2), 109-111 (1998)

Artikel

Butyl methyl ether; Acetic acid; 2-Butanone; Ethyl acetate; Tetrahydrofuran; 1-Butanol; Isopropyl acetate; Heptane; Propyl acetate; 3-Methylbutanol; 4-Methyl-2-pentanone; Isobutyl acetate; Butyl acetate; Dimethyl sulfoxide; Anisole; Cumene

Protokolle

Protocol for GC Analysis of Class 3 Residual Solvents on SUPELCOWAX® 10

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