PHR1187

Retinsäure

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(e): ATRA, Tretinoin, Vitamin-A-Säure, all-trans-Retinsäure
• Empirische Formel (Hill-System): C₂₀H₂₈O₂
• CAS-Nummer: 302-79-4
• Molekulargewicht: 300.44
• Beilstein: 2057223
• EG-Nummer: 206-129-0
• MDL-Nummer: MFCD00001551
• UNSPSC-Code: 41116107
• PubChem Substanz-ID: 329823197
• NACRES: NA.24

Eigenschaften

• Qualität: certified reference material; pharmaceutical secondary standard
• Qualitätsniveau: 300
• Agentur: traceable to Ph. Eur. T1850000; traceable to USP 1674004
• API-Familie: tretinoin
• Form: solid
• Analysenzertifikat (CofA): current certificate can be downloaded
• Methode(n): HPLC: suitable; gas chromatography (GC): suitable
• mp (Schmelzpunkt): 180-181 °C (lit.)
• Anwendung(en): food and beverages
• Format: neat
• Lagertemp.: -10 to -25°C
• SMILES String: CC1=C(\C=C\C(C)=C\C=C\C(C)=C\C(O)=O)C(C)(C)CCC1
• InChI: 1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
• InChIKey: SHGAZHPCJJPHSC-YCNIQYBTSA-N
• Angaben zum Gen: human ... RARA(5914) , RARB(5915) , RARG(5916)

Beschreibung

Allgemeine Beschreibung

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards. Tretinoin is a medication used for the treatment of severe cystic acne. The drug acts by regulating epithelial cell growth and differentiation, sebum production, collagen synthesis and keratinization of the skin.

Anwendung

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Tretinoin may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.

Biochem./physiol. Wirkung

all−trans−Retinsäure (ATRA) ist ein Ligand sowohl für den Retinsäure-Rezeptor (RAR) als auch den Retinoid-X-Rezeptor (RXR). Gebundenes RAR und RXR fungieren als Transkriptionsfaktoren, die das Wachstum und die Differenzierung von normalen und malignen Zellen regulieren. Cytochrom P450 (CYP) katalysiert die 4-Hydroxylierung von ATRA. Retinsäure induziert die Differenzierung embryonaler Stammzellen in neuronale Zellen.

Hinweis zur Analyse

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Sonstige Hinweise

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Fußnote

To see an example of a Certificate of Analysis for this material enter LRAB7354 in the slot below. This is an example certificate only and may not be the lot that you receive.

Sicherheitshinweise

• Piktogramme: GHS08,GHS07,GHS09
• Signalwort: Danger
• H-Sätze: H302,H315,H360FD,H410
• P-Sätze: P202 - P264 - P273 - P301 + P312 - P302 + P352 - P308 + P313
• Gefahreneinstufungen: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 1B - Skin Irrit. 2
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable