PHR1060

Mesalazin

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(e): 5-Aminosalicylsäure, 5-AS, 5-Amino-2-hydroxy-benzoesäure, Mesalazin
• Lineare Formel: H₂NC₆H₃-2-(OH)CO₂H
• CAS-Nummer: 89-57-6
• Molekulargewicht: 153.14
• Beilstein: 2090421
• EG-Nummer: 201-919-1
• MDL-Nummer: MFCD00007877
• UNSPSC-Code: 41116107
• PubChem Substanz-ID: 329823090
• NACRES: NA.24

Eigenschaften

• Qualität: certified reference material; pharmaceutical secondary standard
• Qualitätsniveau: 300
• Agentur: traceable to BP 1075; traceable to Ph. Eur. Y0000297; traceable to USP 1392705
• API-Familie: mesalamine, mesalazine
• Analysenzertifikat (CofA): current certificate can be downloaded
• Methode(n): HPLC: suitable; gas chromatography (GC): suitable
• mp (Schmelzpunkt): 275-280 °C (dec.) (lit.)
• Anwendung(en): pharmaceutical (small molecule)
• Format: neat
• Lagertemp.: 2-30°C
• SMILES String: Nc1ccc(O)c(c1)C(O)=O
• InChI: 1S/C7H7NO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9H,8H2,(H,10,11)
• InChIKey: KBOPZPXVLCULAV-UHFFFAOYSA-N
• Angaben zum Gen: human ... ALOX5(240) , PPARG(5468) , PTGS1(5742) , PTGS2(5743)

Beschreibung

Allgemeine Beschreibung

Mesalamine is a drug, which is structurally similar to salicylates. It exhibits anti-inflammatory activity and is widely used as a medication for the treatment of inflammatory bowel disease, including ulcerative proctitis and Crohn′s disease.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Anwendung

Mesalamine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations using spectrophotometric technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

5-Aminosalicylsäure ist ein Peroxidasesubstrat, geeignet für den Einsatz in ELISA-Verfahren. Dieses Substrat bildet ein lösliches braunes Endprodukt, das spektralphotometrisch bei 450 nm ausgelesen werden kann. Die Reaktion kann mit 3 N NaOH gestoppt und bei 550 nm ausgelesen werden.

Hinweis zur Analyse

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Sonstige Hinweise

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Fußnote

To see an example of a Certificate of Analysis for this material enter LRAA7173 in the slot below. This is an example certificate only and may not be the lot that you receive.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H317,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): No data available
• Flammpunkt (°C): No data available