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D7008

Sigma-Aldrich

Dihydroethidium

≥95% purity, powder

Synonym(e):

2,7-Diamino-10-ethyl-9-phenyl-9,10-dihydrophenanthridin, 3,8-Diamino-5,6-dihydro-5-ethyl-6-phenylphenanthridin, Hydroethidin

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About This Item

Empirische Formel (Hill-System):
C21H21N3
CAS-Nummer:
104821-25-2
Molekulargewicht:
315.41
Beilstein:
5107482
MDL-Nummer:
MFCD00077335
UNSPSC-Code:
12171500
PubChem Substanz-ID:
24894069
NACRES:
NA.47

product name

Dihydroethidium, ≥95%

Qualitätsniveau

100

Assay

≥95%

Form

powder

Farbe

pink to very dark red

Löslichkeit

chloroform: 20 mg/mL

Fluoreszenz

λex 370 nm; λem 420 nm (for cytoplasm of living cells)
λex 535 nm; λem 610 nm (for chromatin of living cells)

Anwendung(en)

diagnostic assay manufacturing
hematology
histology

Lagertemp.

−20°C

SMILES String

CCN1C(c2ccccc2)c3cc(N)ccc3-c4ccc(N)cc14

InChI

1S/C21H21N3/c1-2-24-20-13-16(23)9-11-18(20)17-10-8-15(22)12-19(17)21(24)14-6-4-3-5-7-14/h3-13,21H,2,22-23H2,1H3

InChIKey

XYJODUBPWNZLML-UHFFFAOYSA-N

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Verwandte Kategorien

Anwendung

Redox-Indikator. Blaue Fluoreszenz vor der Oxidation zu Ethidium.
Dihydroethidium has been used as a superoxide probe in bovine pulmonary artery endothelial cell (BPAEC). It has been used to check the in situ generation of ROS (reactive oxygen species).

Verpackung

abgefüllt unter Argon

Verlinkung

B-Ring reduziertes Analogon von Ethidium

Ähnliches Produkt

Produkt-Nr.
Beschreibung
Preisangaben

06693

Timestrip Plus™ -20 °C

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Analysenzertifikate (COA)

Lot/Batch Number
MKCN1192
MKCL7544
MKCL1719
MKCK8723
MKCK3321

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20-HETE increases superoxide production and activates NAPDH oxidase in pulmonary artery endothelial cells.
Medhora M, et al.
American Journal of Physiology. Lung Cellular and Molecular Physiology, 294, L902-L911 (2008)
Quercetin reduces oxidative stress and inhibits activation of c-Jun N-terminal kinase/activator protein-1 signaling in an experimental mouse model of abdominal aortic aneurysm.
Wang L, et al.
Molecular Medicine Reports, 9, 435-442 (2014)
Cira Rubies et al.
Scientific reports, 9(1), 11443-11443 (2019-08-09)
Obstructive sleep apnea syndrome (OSA) promotes aortic dilatation, increased stiffness and accelerated atherosclerosis, but the mechanisms of vascular remodelling are not known. We aimed to assess vascular remodelling, its mechanisms, and the effect of mesenchymal stem cells (MSC) infusions in
Anna Rita Fetoni et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(9), 4011-4023 (2013-03-01)
This study addresses the relationship between cochlear oxidative damage and auditory cortical injury in a rat model of repeated noise exposure. To test the effect of increased antioxidant defenses, a water-soluble coenzyme Q10 analog (Qter) was used. We analyzed auditory
Rossarin Suwanarusk et al.
The Journal of antimicrobial chemotherapy, 70(1), 124-129 (2014-08-26)
Methylene blue, once discarded due to its unsettling yet mild side effects, has now found a renewed place in the pharmacopoeia of modern medicine. The continued spread of drug-resistant Plasmodium vivax and Plasmodium falciparum has also led to a recent
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