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Merck

SCC071

Sigma-Aldrich

UM-SCC-47 HPV-16 Positive Squamous Carcinoma Cell Line

Human

Synonym(e):

University Michigan Squamous Cell Carcinoma, UMSCC47, H&N squamous cell carcinoma cell line, Head and neck squamous cell carcinoma cell line, HNSCC

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About This Item

UNSPSC-Code:
41106514
eCl@ss:
32011203
NACRES:
NA.81

product name

UM-SCC-47 HPV-16 Positive Squamous Carcinoma Cell Line, suitable in vitro model of H&N carcinoma studies

Biologische Quelle

human

Qualitätsniveau

Methode(n)

cell culture | mammalian: suitable

Versandbedingung

liquid nitrogen

Allgemeine Beschreibung

All UM-SCC cell lines were derived in the lab of Dr. Thomas Carey at the University of Michigan and are exclusively distributed by Merck KGaA, Darmstadt, Germany. Access to UM-SCC cells is limited solely to those officers, employees and students of PURCHASER’s institution who need access to perform research. PURCHASER may not distribute UM-SCC cells or derivatives to third parties. PURCHASER shall comply with all applicable laws in its use and handling of the Product and shall keep it under reasonable safe and secure conditions to prevent unauthorized use or access.

THIS PRODUCT IS ONLY AVAILABLE FOR SALE TO ACADEMIC INSTITUTIONS OR NOT-FOR-PROFIT ENTITIES FOR USE UNDER THIS LIMITED USE LABEL LICENSE. FOR INFORMATION ON COMMERCIAL LICENSING OF UM-SCC CELLS, INCLUDING LICENSING TO COMMERCIAL ENTITIES, PLEASE CONTACT: licensing@emdmillipore.com

Head and neck squamous-cell carcinoma (HNSCC) is the 6th most common type of cancer world-wide. The cancer may occur in the lip, oral cavity, nasal cavity, paranasal sinuses, salivary glands, pharynx and larynx. Risk factors include smoking, alcohol consumption, betel nut chewing, wood dust exposures and human papilloma virus (HPV) infections. Approximately 15% of HNSCC contain genomic DNA from HPV. In particular, HPV-16 occurs in 90-95% of all HPV-positive HNSCC cases. In oral and pharynx cancer, HPV DNA is found in the tonsils in 45-67% of the cases. HPV DNA is found in 13-25% of the cases in the hypopharynx, 12-18% in the oral cavity and 3-7% in the larynx.

UM-SCC-47 is a unique head and neck squamous carcinoma cell line isolated from the primary tumor of the lateral tongue of a male patient. The cell line contains 18 copies of integrated HPV-16.

UM-SCC-47 was established at the University of Michigan with written informed consent obtained from the patient and with the approval of the study by the Medical School Institutional Review Board.

Reference:
1) Carey, T., et al. (2012) Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell lines. Head Neck. 2010 April; 32(4): 417–426.

Beschreibung der Zelllinie

Cancer Cells

Anwendung

Research Category
Infektionskrankheiten

Entzündung & Immunologie

Apoptose & Krebs
This product is available for sale to academic institutions or not-for-profit entities for research use. For information on commercial licensing please contact licensing@emdmillipore.com.

Komponenten

1) ≥1X106 viable UM-SCC-47 Squamous Carcinoma Cells: (Catalog No. SCC071). Store in liquid nitrogen.

Qualität

• Each vial contains ≥ 1X10^6 viable cells.
• Cells are tested by PCR and are positive for HPV-16 and negative for Hepatitis A, B, C and HIV-1 & 2 viruses.
• Cells are negative for mycoplasma contamination.
• Each lot of cells are genotyped by STR analysis to verify the unique identity of the cell line.

Lagerung und Haltbarkeit

UM-SCC-47 cells should be stored in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Lagerklassenschlüssel

6.2 - Infectious substances

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Julia E Myers et al.
Current protocols in microbiology, 59(1), e119-e119 (2020-10-17)
Integration of the human papillomavirus (HPV) genome into host cell chromosomes has been observed in a majority of HPV-positive cervical cancers and a subset of oral HPV-associated cancers. HPV integration also occurs in long-term cell culture. Screening for HPV integration

Artikel

AldeRed™ 588-A is a red fluorescent live cell probe that detects ALDH activity used to identify cancer stem cells and progenitor cells in culture. Cancer stem cells (CSCs) are subpopulations of cancer cells that can self-renew, generate diverse cells in the tumor mass, and sustain tumorigenesis. Some researchers believe that cancer arises from cancer stem cells that originate as a result of mutational hits on normal stem cells.

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

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