MABT36

Anti-COMP (Thrombospondin-5) Antibody, clone 484D1

clone 484D1, from rat

• Synonym(e): Cartilage oligomeric matrix protein, Thrombospondin-5
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rat
• Qualitätsniveau: 100
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: 484D1, monoclonal
• Speziesreaktivität: human
• Methode(n): immunohistochemistry: suitable; western blot: suitable
• Isotyp: IgG1κ
• NCBI-Hinterlegungsnummer: NP_000086
• UniProt-Hinterlegungsnummer: P49747
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... COMP(1311)

Beschreibung

Allgemeine Beschreibung

Cartilage oligomeric matrix protein (COMP, Thrombospondin-5, TSP5) is a member of the thrombospondin gene family. COMP is usually found in the extracellular matrix and is regularly linked to cartilage tissue. COMP seems to protect chondrocytes against cell death, whether tumor necrosis factor alpha is present or not. Defects in COMP are the cause of multiple epiphyseal dysplasia type 1 and pseudoachondroplasia.

Immunogen

Human cartilage oligometric matrix recombinant protein.

Anwendung

Research Category
Zellstruktur

Research Sub Category
ECM-Proteine

Immunohistochemistry (Frozen Tissue) Analysis: A previous lot of this antibody was shown to detect COMP in osteoblasts lining the bone spicules of adult human subchondral bone section (Di Cesare, P.E., et al. (2000). Journal of Orthopaedic Research. 18:713.720).

This Anti-COMP (Thrombospondin-5) Antibody, clone 484D1 is validated for use in WB, IH for the detection of COMP (Thrombospondin-5).

Qualität

Evaluated by Western Blot in human chrondrocytes cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected COMP in 10 µg of human chrondrocyte cell lysate.

Zielbeschreibung

~83 kDa Observed

Physikalische Form

Protein G Purified

Format: Purified

Purified rat monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Lagerung und Haltbarkeit

Stable for 1 year at 2-8°C from date of receipt.

Hinweis zur Analyse

Control
Human chrondrocyte cell lysate

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable