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MABF406

Sigma-Aldrich

Anti-CD279 (PD-1) Antibody (mouse), PE, clone J43.1

clone J43.1, 0.2 mg/mL, from hamster(Armenian)

Synonym(e):

Programmed cell death protein 1, Protein PD-1, mPD-1, CD279

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

hamster (Armenian)

Qualitätsniveau

Konjugat

PE

Antikörperform

purified antibody

Antikörper-Produkttyp

primary antibodies

Klon

J43.1, monoclonal

Speziesreaktivität

mouse

Konzentration

0.2 mg/mL

Methode(n)

flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable

Isotyp

IgG

UniProt-Hinterlegungsnummer

Versandbedingung

wet ice

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

mouse ... Pdcd1(18566)

Allgemeine Beschreibung

The J43.1 antibody is specific for mouse CD279, also known as programmed death-1 (PD-1), a 55 kDa glycoprotein which can co-regulate T cell antigen receptor signaling and therefore modulate T cell activation. PD-1 exists in a monomeric form that is expressed by CD4- CD8- thymocytes, where it participates in the processes of clonal selection, elimination of autoreactive lymphocytes, and development of tolerance. PD-1 expression is also inducible upon activation of mature T cells, where it has been proposed to interact with the co-stimulatory receptor CD80 to limit T cell activation. Two ligands for PD-1, known as PD-L1 (B7-H1) and PD-L2 (B7-DC) are differentially expressed on T and B cells, monocytes, macrophages, NK cells or dendritic cells. PD-1 is a member of a family of receptors including CD28 and CTLA-4 (CD152), which interact with “B7” ligands to provide a balance of co-stimulatory /co-inhibitory signaling important in T cell activation, tolerance, and autoimmunity.The J43.1 antibody may be used as a marker for PD-1 expression, and is commonly used for analysis of receptor-ligand interaction and function(s) in vitro and in vivo.

Immunogen

Immunogen information for this antibody is proprietary information.

Anwendung

Research Category
Entzündung & Immunologie
This armenian hamster monoclonal antibody Anti-CD279 (PD-1) (mouse), PE, clone J43.1 validated for use in IP, IHC & Flow Cytometry for the detection of CD279 (PD-1).

Qualität

The monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Flow Cytometry Analysis: 0.5 µg of this antibody detected CD279 (PD-1) in one million C57Bl/6 splenocytes.

Physikalische Form

Size Exclusion Chromatography
Purified Armenian Hamster Monoclonal Antibody in buffer containing 10 mM NaH2PO4, 150 mM NaCl, 0.1% gelatin, pH 7.2, and up to 0.1% sodium azide.

Lagerung und Haltbarkeit

It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

12 - Non Combustible Liquids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


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