MABF272

Anti-TREM-1, clone 2(1a2) Antibody

clone 2(1a2), from mouse, Atto 550 conjugate

• Synonym(e): Triggering receptor expressed on myeloid cells 1, TREM-1, Triggering receptor expressed on monocytes 1, CD354
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 100
• Konjugat: Atto 550 conjugate
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: 2(1a2), monoclonal
• Speziesreaktivität: human
• Methode(n): flow cytometry: suitable
• Isotyp: IgG2bκ
• NCBI-Hinterlegungsnummer: NP_001229518
• UniProt-Hinterlegungsnummer: Q9NP99
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... TREM1(54210)

Beschreibung

Allgemeine Beschreibung

Triggering receptor expressed on myeloid cells 1 (TREM-1) is a membrane bound protein and secreted protein that is expressed by most cells in many tissues including liver, lung, spleen, lymph node, heart, and even spinal cord in response to bacterial and fungal infections. TREM-1 stimulates neutrophil and monocyte mediated inflammatory responses. TREM-1 also triggers pro-inflammatory chemokines and cytokines as well as increases surface expression of cell activation markers like CD11, thus TREM-1 acts as an amplifier of inflammatory responses in response to these pathogens. TREM-1 similarly is a potent LPS response factor and its expression is upregulated by LPS released by bacterial and fungal infections, and thus TREM-1 is a critical mediator of septic shock caused by such infections.

Immunogen

Recombinant protein corresponding to human TREM-1.

Anwendung

Research Category
Entzündung & Immunologie

Research Sub Category
Immunoglobuline & Immunologie

This Anti-TREM-1, clone 2(1a2) Antibody is validated for use in Flow Cytometry for the detection of TREM-1.

Qualität

Evaluated by Flow Cytometry in human peripheral blood mononuclear.

Flow Cytometry Analysis: 0.25 µg of this antibody detected TREM-1 in human peripheral blood mononuclear cells.

Zielbeschreibung

26 kDa calculated

Physikalische Form

Protein G Purified

Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Lagerung und Haltbarkeit

Stable for 1 year at 2-8°C from date of receipt.

Sonstige Hinweise

Concentration: Please refer to lot specific datasheet.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 2