MAB394-100UG
Anti-Dopamine β Hydroxylase-SAP Antibody, clone 4F10.2
clone 4F10.2, Chemicon®, from mouse
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About This Item
UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Empfohlene Produkte
Biologische Quelle
mouse
Qualitätsniveau
Konjugat
saporin
Antikörper-Produkttyp
primary antibodies
Klon
4F10.2, monoclonal
Speziesreaktivität
rat
Hersteller/Markenname
Chemicon®
Methode(n)
immunolesioning: suitable
Isotyp
IgG1
NCBI-Hinterlegungsnummer
UniProt-Hinterlegungsnummer
Versandbedingung
dry ice
Posttranslationale Modifikation Target
unmodified
Angaben zum Gen
rat ... Dbh(25699)
Spezifität
Dopamine b-HydroxylaseDBH is a single gene product that exists as a cytosolic enzyme, as a membrane protein and is secreted into the circulation (Lewis & Asnani, 1992). Because of its residence time as a plasma membrane-bound protein, it is able to be used as a targeting agent for neurons. The target neurons include postganglionic sympathetic neurons and all noradrenergic and adrenergic neurons of the central nervous system. As such anti-DBH-SAP can be used for the production of acute peripheral autonomic failure in a model for the human disease. It can also be used for the analysis of the behavioral effects of noradrenergic or adrenergic ablation. When injected intraventricularly, noradrenergic neurons of the locus coeruleus are eliminated (Wiley & Lappi, 1994). The antibody and immunotoxin undergo retrograde transport.
MAB308 is the unconjugated monoclonal.
MAB308 is the unconjugated monoclonal.
Anwendung
Research Category
Neurowissenschaft
Neurowissenschaft
Research Sub Category
Neurodegenerative Krankheiten
Neurodegenerative Krankheiten
Detect Dopamine β Hydroxylase using this Anti-Dopamine β Hydroxylase-SAP Antibody, clone 4F10.2 validated for use in 0.
Immunotoxin
Physikalische Form
Saporin Conjugated. Sterile liquid. Provided in phosphate buffered saline. Contains no preservative.
Lagerung und Haltbarkeit
The material should be stored at -80°C for up to six months under sterile conditions. Avoid repeated freeze-thaw cycles.
Sonstige Hinweise
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Rechtliche Hinweise
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Lagerklassenschlüssel
12 - Non Combustible Liquids
WGK
WGK 2
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Analysenzertifikate (COA)
Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.
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Carolina Rocha-Pereira et al.
Journal of pharmacological sciences, 122(2), 59-70 (2013-06-21)
In hypertension, vascular reactivity alterations have been attributed to numerous factors, including higher sympathetic innervation/adenosine. This study examined the modulation of adenosine receptors on vascular sympathetic nerves and their putative contribution to higher noradrenaline spillover in hypertension. We assessed adenosine
C C Wrenn et al.
Brain research, 740(1-2), 175-184 (1996-11-18)
The ability to create lesions of discrete neuronal populations is an important strategy for clarifying the function of these populations. The power of this approach is critically dependent upon the selectivity of the experimental lesioning technique. Anti-neuronal immunotoxins offer an
Soluble and membrane-bound forms of dopamine beta-hydroxylase are encoded by the same mRNA.
Lewis, E J and Asnani, L P
The Journal of Biological Chemistry, 267, 494-500 (1992)
M J Picklo et al.
The Journal of pharmacology and experimental therapeutics, 275(2), 1003-1010 (1995-11-01)
Anti-dopamine beta-hydroxylase immunotoxin (DHIT) is an antibody-targeted noradrenergic lesioning tool comprised of a monoclonal antibody against the noradrenergic enzyme, dopamine beta-hydroxylase, conjugated to saporin, a ribosome-inactivating protein. Noradrenergic-neuron specificity and completeness and functionality of sympathectomy were assessed. Adult, male Sprague-Dawley
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