ABE69

Anti-PTIP Antibody

from chicken, purified by affinity chromatography

• Synonym(e): PAX interacting (with transcription-activation domain) protein 1, PAX transactivation activation domain-interacting protein, protein encoded by CAG trinucleotide repeats, PAX transcription activation domain interacting protein 1 like
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: chicken
• Qualitätsniveau: 100
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Aufgereinigt durch: affinity chromatography
• Speziesreaktivität: rat, mouse, human
• Methode(n): immunofluorescence: suitable; immunohistochemistry: suitable; western blot: suitable
• NCBI-Hinterlegungsnummer: NP_031375
• UniProt-Hinterlegungsnummer: Q6ZW49
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... PAXIP1(22976)

Beschreibung

Allgemeine Beschreibung

PAX transactivation activation domain-interacting protein (PTIP) is a ubiquitous nuclear protein composed of 5 tandem BRCA1 carboxyl-terminal (BRCT) domains. PTIP was initially identified as an interacting, transactivation protein that binds to the C-terminal end of Pax2. Since its discovery, studies have shown PTIP to bind several Pax proteins, playing a critical role in response to DNA damage. It also has activity as a phosphoserine/ phosphothreonine-specific binding module, and can discern ATM and ATR gamma irradiation induced phosphorylated substrates. PTIP is involved in early cellular development and is likely to have a role in cell proliferation as well.

Immunogen

Histidine-tagged recombinant protein corresponding to human PTIP.

Anwendung

Research Category
Epigenetik & nukleäre Funktionen

Research Sub Category
Chromatin-Biologie (ChIP)

Anti-PTIP Antibody is a Chicken Polyclonal Antibody for detection of PTIP also known as PAX transactivation activation domain-interacting protein, protein encoded by CAG trinucleotide repeats & has been validated in WB, IHC & IF.

Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in IH (Patel, S., et al. (2007).

Immunofluorescence Analysis: A represenative lot was used by an independent laboratory in IF (Lechner, M., et al. (2000).

Qualität

Evaluated by Western Blot in A431 cell lysate.

Western Blot Analysis: A 1:1,000 dilution of this antibody detected PTIP in 10 µg of A431 cell lysate.

Zielbeschreibung

~120 kDa observed.
Other isoforms may be observed in some lysates.

Physikalische Form

Affinity purified

Purified chicken polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Lagerung und Haltbarkeit

Stable for 1 year at 2-8°C from date of receipt.

Hinweis zur Analyse

Control
A431 cell lysate

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable