Direkt zum Inhalt
Merck
Alle Fotos(1)

Wichtige Dokumente

AB9750

Sigma-Aldrich

Anti-14-3-3 phospho Serine58 Antibody

Chemicon®, from rabbit

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise
Alle Fotos(1)

About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

100

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Aufgereinigt durch

affinity chromatography

Speziesreaktivität

rat, human

Hersteller/Markenname

Chemicon®

Methode(n)

western blot: suitable

NCBI-Hinterlegungsnummer

NM_006761.3

UniProt-Hinterlegungsnummer

P62258

Versandbedingung

dry ice

Posttranslationale Modifikation Target

phosphorylation (pSer58)

Angaben zum Gen

human ... YWHAE(7531)

Spezifität

14-3-3 Protein, phosphoSerine58. The antibody recognizes a protein of ~29 kDa corresponding to 14-3-3 Protein, phosphoSerine58 in lysates from rat brainstem. Immunolabeling is blocked by the phosphopeptide used as the immunogen but not the corresponding non-phosphopeptide.
The immunogen sequence has 100% conservation with mouse and Xenopus.

Immunogen

Synthetic peptide of amino acids surrounding the phosphoSerine 58 site of rat 14-3-3 Protein.

Anwendung

Research Category
Neurowissenschaft
Research Sub Category
Neurodegenerative Krankheiten
Anti-14-3-3 phospho Serine58 Antibody detects level of 14-3-3 phospho Serine58 & has been published & validated for use in WB.
Western blot: 1:1,000

Physikalische Form

ImmunoAffinity Purified
Liquid in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50% glycerol.

Lagerung und Haltbarkeit

Maintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self defrosting freezer.

Rechtliche Hinweise

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sie haben nicht das passende Produkt gefunden?  

Probieren Sie unser Produkt-Auswahlhilfe. aus.

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 2

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

14-3-3 proteins in the nervous system
Berg, Daniela, et al
Nature Reviews. Neuroscience, 4, 752-762 (2003)
Unlocking the code of 14-3-3.
Dougherty, Michele K and Morrison, Deborah K
Journal of Cell Science, 117, 1875-1884 (2004)
Joanna M Woodcock et al.
The Journal of biological chemistry, 278(38), 36323-36327 (2003-07-17)
The 14-3-3 proteins play a central role in the regulation of cell growth, cycling, and apoptosis by modulating the functional activities of key signaling proteins. Through binding to a phosphoserine motif, 14-3-3 alters target proteins activities by sequestering them, relocalizing
14-3-3 proteins: a number of functions for a numbered protein
Bridges, D. and Moorhead, G.B.G.
Science's STKE : Signal Transduction Knowledge Environment, 2005, re10-re10 (2005)
Jan Silhan et al.
The Journal of biological chemistry, 279(47), 49113-49119 (2004-09-07)
14-3-3 proteins are important regulators of numerous cellular signaling circuits. They bind to phosphorylated protein ligands and regulate their functions by a number of different mechanisms. The C-terminal part of the 14-3-3 protein is known to be involved in the

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung.