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Key Documents

16-233

Sigma-Aldrich

Anti-FAK Antibody, clone 4.47, Alexa Fluor™ 488 conjugate

clone 4.47, Upstate®, from mouse

Synonym(e):

Anti-FADK, Anti-FADK 1, Anti-FAK, Anti-FAK1, Anti-FRNK, Anti-PPP1R71, Anti-p125FAK, Anti-pp125FAK

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

mouse

Qualitätsniveau

100

Konjugat

ALEXA FLUOR™ 488

Antikörperform

purified immunoglobulin

Antikörper-Produkttyp

primary antibodies

Klon

4.47, monoclonal

Speziesreaktivität

human, rat, mouse

Hersteller/Markenname

Upstate®

Methode(n)

flow cytometry: suitable
immunocytochemistry: suitable
western blot: suitable

Isotyp

IgG1

NCBI-Hinterlegungsnummer

NM_005607.3
NM_153831.2

UniProt-Hinterlegungsnummer

Q05397

Versandbedingung

wet ice

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... PTK2(5747)

Spezifität

p125FAK, does not cross react with Pyk-2

Immunogen

GST fusion protein corresponding to residues 1-423 of human FAK (focal adhesion kinase)

Anwendung

Research Category
Zelluläre Signaltransduktion
Research Sub Category
Cytoskelettale Signalübertragung
Detect FAK using this Anti-FAK Antibody, clone 4.47, Alexa Fluor 488 conjugate validated for use in FC, WB & IC.

Qualität

Routinely evaluated by immunostaining of 3T3 cells.

Zielbeschreibung

125kDa

Physikalische Form

Protein G Purified

Lagerung und Haltbarkeit

1 year at 4°C from date of shipment

Rechtliche Hinweise

ALEXA FLUOR is a trademark of Life Technologies
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Alexa Fluor™ is a registered trademark of Molecular Probes, Inc.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

12 - Non Combustible Liquids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Steven K Hanks et al.
Frontiers in bioscience : a journal and virtual library, 8, d982-d996 (2003-04-18)
Focal adhesion kinase (FAK) was first described in 1992 as a novel nonreceptor protein-tyrosine kinase localized prominently within focal adhesions, suggesting a signaling role in regulating cell behavior resulting from integrin interaction with the extracellular matrix. Subsequent studies over the
Focal adhesion kinase: in command and control of cell motility.
Mitra, Satyajit K, et al.
Nature Reviews in Molecular and Cell Biology, 6, 56-68 (2005)
Control of motile and invasive cell phenotypes by focal adhesion kinase.
Schlaepfer, David D, et al.
Biochimica et Biophysica Acta, 1692, 77-102 (2004)
Julia Meller et al.
JCI insight, 2(11) (2017-06-02)
Microglia play a critical role in the development and homeostasis of the CNS. While mobilization of microglia is critical for a number of pathologies, understanding of the mechanisms of their migration in vivo is limited and often based on similarities
FAK and paxillin: regulators of N-cadherin adhesion and inhibitors of cell migration?
Schaller, Michael D
The Journal of cell biology, 166, 157-159 (2004)
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