13-107
Core Histones
Highly pure core histones proteins (H2A, H2B, H3 and H4) including H1 purified from chicken erythrocytes, suitable as a substrate for histone modification assays (HAT, HDAC, DNMT) and nucleosome assembly studies.
Synonym(e):
Core Histone Proteins
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About This Item
UNSPSC-Code:
12352200
eCl@ss:
32160405
NACRES:
NA.32
Empfohlene Produkte
Biologische Quelle
chicken
Hersteller/Markenname
Upstate®
Methode(n)
activity assay: suitable (histone acetyltransferase (HAT))
Versandbedingung
dry ice
Allgemeine Beschreibung
Histones are a family of basic proteins that associate with DNA in the nucleus and help condense it into chromatin. Some histones function as spools for the thread-like DNA to wrap around forming a nucleosome. Each nucleosome is made of DNA wrapped around eight histone proteins that function like a spool and are called a histone octamer. Each histone octamer is composed of two copies each of the histone proteins H2A, H2B, H3, and H4. The chain of nucleosomes is then wrapped into a 30 nm spiral called a solenoid, where additional H1 histone proteins are associated with each nucleosome to maintain the chromosome structure.
Anwendung
Core histones and histone H1, purified from chicken erythrocytes; suitable as a substrate for HAT assays; purity = 90%
Qualität
rountinely evaluated by immunoblot using Anti-Histone H3 (05-499) and Anti-Histone H4 (07-108)
Physikalische Form
Lyophilized
Lagerung und Haltbarkeit
Lyophilized: 2 years at -20°C; Rehydrated: 6 months at -70°C
Rechtliche Hinweise
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 2
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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