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06-756

Sigma-Aldrich

Anti-Frizzled 5 Antibody

Upstate®, from rabbit

Synonym(e):

Fz5, Fzd5

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

Antikörperform

purified immunoglobulin

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Speziesreaktivität

rat, human, mouse

Hersteller/Markenname

Upstate®

Methode(n)

western blot: suitable

Isotyp

IgG

NCBI-Hinterlegungsnummer

UniProt-Hinterlegungsnummer

Versandbedingung

wet ice

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... FZD5(7855)

Allgemeine Beschreibung

The Wnt family consists of ligands involved in cell fate determination, organogenesis, and oncogenesis. The Wnt signal is thought to be transduced sequentially via a homolog of the frizzled family of receptors to GSK-3 (disheveled), β- and γ- catenin and finally to members of the Tcf/Lef-1 family of HMG box transcription factors. Frizzled 5 is believed to function as the receptor for the Wnt5a ligand.

Spezifität

Frizzled 5 (aka Fz5 or Fzd5)

Immunogen

Epitope: C-Terminus
KLH-conjugated, synthetic peptide derived from amino acids 564-585 of human Frizzled 5 (CTGRTPPGPAATYHKQVSLSHV).

Anwendung

Research Category
Zelluläre Signaltransduktion
Research Sub Category
Entwicklungsabhängige Signalübertragung

GPCR-, cAMP/cGMP- & kalziumabhängige Signalübertragung
Anti-Frizzled 5 Antibody is an antibody against Frizzled 5 for use in WB.

Qualität

Routinely evaluated by immunoblot on lysates from mouse liver, C2C12, Jurkat or HUVEC cells

Zielbeschreibung

Frizzled 5 (62kDa)

Physikalische Form

Protein A chromatography
Format: Purified
Purified antibody in PBS with 0.05% sodium azide and 30% Glycerol

Lagerung und Haltbarkeit

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Hinweis zur Analyse

Control
Lysates from mouse liver, C2C12, Jurkat, and HUVEC

Rechtliche Hinweise

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1


Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

WNT-5A stimulates the GDP/GTP exchange at pertussis toxin-sensitive heterotrimeric G proteins.
Michaela Bc Kilander,Jacomijn P Dijksterhuis,Ranjani Sri Ganji,Vitezslav Bryja,Gunnar Schulte
Cellular Signalling null
Wnt-frizzled signaling in the induction and differentiation of the neural crest.
Yanfeng, Wang, et al.
Bioessays, 25, 317-325 (2003)
The Frizzled family: receptors for multiple signal transduction pathways.
Huang, Hui-Chuan and Klein, Peter S
Genome Biology, 5, 234-234 (2004)
Y Wang et al.
The Journal of biological chemistry, 271(8), 4468-4476 (1996-02-23)
In Drosophila melanogaster, the frizzled gene plays an essential role in the development of tissue polarity as assessed by the orientation of cuticular structures. Through a combination of random cDNA sequencing, degenerate polymerase chain reaction amplification, and low stringency hybridization
A Bafico et al.
The Journal of biological chemistry, 274(23), 16180-16187 (1999-05-29)
Frizzled related proteins (FRPs) comprise a family of secreted molecules that contain an N-terminal cysteine-rich domain (CRD) highly similar to the CRDs of the frizzled family of membrane-anchored Wnt receptors. FRPs have been shown to interact with Wnt proteins and

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