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Key Documents

05-449

Sigma-Aldrich

Anti-Bin1 Antibody, clone 99D

clone 99D, Upstate®, from mouse

Synonym(e):

Anti-AMPH2, Anti-AMPHL, Anti-CNM2, Anti-SH3P9

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

mouse

Qualitätsniveau

100

Antikörperform

purified antibody

Antikörper-Produkttyp

primary antibodies

Klon

99D, monoclonal

Speziesreaktivität

rat, human, mouse

Hersteller/Markenname

Upstate®

Methode(n)

immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

Isotyp

IgG1κ

NCBI-Hinterlegungsnummer

NM_139343

UniProt-Hinterlegungsnummer

O00499

Versandbedingung

dry ice

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... BIN1(274)
mouse ... Bin1(30948)

Spezifität

Bin1

Immunogen

Partial fusion protein corresponding to amino acids 189-398 of human Bin1. Clone 99D

Anwendung

Research Category
Apoptose & Krebs
Research Sub Category
BCL2 & Hemmung
Anti-Bin1 Antibody, clone 99D is an antibody against Bin1 for use in IP, WB, IH.

Qualität

routinely evaluated by immunoblot on RIPA lysate of C2C12 cells.

Zielbeschreibung

56kDa

Verlinkung

Replaces: MAB4131

Physikalische Form

Protein G Chromatography
0.1M Tris-glycine, pH 7.4, containing 0.05% sodium azide
Format: Purified

Lagerung und Haltbarkeit

1 year at -20°C

Sonstige Hinweise

Due to license agreement restrictions, this product cannot be purchased for resale.

Rechtliche Hinweise

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

12 - Non Combustible Liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Suppression of MEK/ERK signalling by Myc: role of Bin-1.
Telfer, JF; Urquhart, J; Crouch, DH
Cellular Signalling null
R Wechsler-Reya et al.
Cancer research, 57(15), 3258-3263 (1997-08-01)
BIN1 is a putative tumor suppressor that was identified in a genetic screen for polypeptides that interact with the MYC oncoprotein. Using a set of six monoclonal antibodies, we identified and examined biochemical features and localization of cellular BIN1. Epitope
Tiago Mendes et al.
Current protocols in cell biology, 86(1), e100-e100 (2019-12-27)
The proximity ligation assay (PLA) allows the detection and subcellular localization of protein-protein interactions with high specificity. We recently developed a high-content screening model based on primary hippocampal neurons cultured in 384-well plates and screened a library of ∼1100 compounds
R J Wechsler-Reya et al.
Molecular and cellular biology, 18(1), 566-575 (1998-01-07)
Bin1 is a Myc-interacting protein with features of a tumor suppressor. The high level of Bin1 expression in skeletal muscle prompted us to investigate its role in muscle differentiation. Significant levels of Bin1 were observed in undifferentiated C2C12 myoblasts, a
Maxime Sartori et al.
Acta neuropathologica, 138(4), 631-652 (2019-05-09)
The bridging integrator 1 gene (BIN1) is a major genetic risk factor for Alzheimer's disease (AD). In this report, we investigated how BIN1-dependent pathophysiological processes might be associated with Tau. We first generated a cohort of control and transgenic mice
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