D-049

N-Desmethylclobazam solution

100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant^®

• Empirische Formel (Hill-System): C₁₅H₁₁ClN₂O₂
• CAS-Nummer: 22316-55-8
• Molekulargewicht: 286.71
• EG-Nummer: 200-835-2
• MDL-Nummer: MFCD00871860
• UNSPSC-Code: 41116107
• PubChem Substanz-ID: 329798612
• NACRES: NA.24

Eigenschaften

• Qualität: certified reference material
• Qualitätsniveau: 300
• Form: liquid
• Leistungsmerkmale: Snap-N-Spike^®/Snap-N-Shoot^®
• Verpackung: ampule of 1 mL
• Hersteller/Markenname: Cerilliant^®
• Konzentration: 100 μg/mL in acetonitrile
• Methode(n): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• Anwendung(en): clinical testing
• Format: single component solution
• Lagertemp.: −20°C
• SMILES String: O=C(C1)N(C2=CC=CC=C2)C3=C(C=CC(Cl)=C3)NC1=O
• InChI: 1S/C15H11ClN2O2/c16-10-6-7-12-13(8-10)18(11-4-2-1-3-5-11)15(20)9-14(19)17-12/h1-8H,9H2,(H,17,19)
• InChIKey: RRTVVRIFVKKTJK-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

A Certified Solution Standard for use in LC or GC applications from forensic and forensic toxicology analysis to urine drug testing. N-Desmethylclobazam, found in urine, serum, and plasma, is the pharmacologically active, major metabolite of clobazam.

Anwendung

• Impact on bioavailability in epilepsy treatment: A study discussed the implications of N-Desmethylclobazam on drug to drug interactions and neuropsychological impact when used as add-on therapy in drug-resistant epilepsies, highlighting its role in enhancing therapeutic bioavailability (Pietrafusa et al., 2023).



• Research on pharmacokinetic variability: Research explored the pharmacokinetic variability of N-Desmethylclobazam, emphasizing its influence by age, drug interactions, and biochemical markers of toxicity in patients with epilepsy, contributing to a deeper understanding of its pharmacological properties (Heger et al., 2024).



• Evaluation of drug-drug interactions: A comprehensive analysis investigated potential drug-drug interactions between N-Desmethylclobazam and anti-seizure medications, providing insights into its safe and effective use in clinical settings (Gaston et al., 2023).



• Synergistic effects in epilepsy management: A multicenter study on the cenobamate-clobazam interaction revealed both pharmacokinetic interactions and evidence of synergy, underscoring N-Desmethylclobazam′s potential to enhance treatment outcomes in epilepsy (Osborn and Abou-Khalil, 2023).



• Analysis of metabolites in forensic science: Research on the measurement of benzodiazepine receptor agonists′ metabolites, including N-Desmethylclobazam, outlined its detection and concentration levels in urine, offering applications in forensic toxicology (Volkova et al., 2023).

Rechtliche Hinweise

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Piktogramme: GHS02,GHS07
• Signalwort: Danger
• H-Sätze: H225,H302 + H312 + H332,H319
• P-Sätze: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
• Lagerklassenschlüssel: 3 - Flammable liquids
• WGK: WGK 2
• Flammpunkt (°F): 35.6 °F - closed cup
• Flammpunkt (°C): 2 °C - closed cup