810601P
Avanti
16:0-5 Doxyl PC
Avanti Research™ - A Croda Brand 810601P, powder
Synonym(e):
1-palmitoyl-2-stearoyl-(5-doxyl)-sn-glycero-3-phosphocholine
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Alle Fotos(1)
About This Item
Empirische Formel (Hill-System):
C46H90N2O10P
CAS-Nummer:
Molekulargewicht:
862.19
UNSPSC-Code:
41141825
NACRES:
NA.25
Empfohlene Produkte
Assay
>99% (TLC)
Form
powder
Verpackung
pkg of 1 × 1 mg (810601P-1mg)
Hersteller/Markenname
Avanti Research™ - A Croda Brand 810601P
Lipid-Typ
ESR probes
phospholipids
Versandbedingung
dry ice
Lagertemp.
−20°C
Allgemeine Beschreibung
Avanti′s nitroxide spin product listing is a group of compounds designed to act as membrane probes. A variety of positions down the hydrophobic chain are labeled with the nitroxide functional groups to allow probing the membrane at various depths. These compounds have been synthesized from 1-palmitoyl-2-hydroxy-sn-glycerol-3-phosphocholine with the product being purified by column chromatography. Various n-doxyl phosphocholines have been recently used as biophysical tools to elucidate membrane trafficking with phosphatidylinositol transfer proteins and as fluorescent quenchers in lipid bilayer structural studies.
Phosphatidylcholine (PC), a strong bilayer-forming lipid is the most common phospholipid in mammalian membranes. The excretory and secretory products of helminths has a small hapten-like portion called phosphorylcholine (PC). The 5th carbon of the sn-2 stearic acid chain of 1-palmitoyl-2-stearoyl-(5-doxyl)-sn-glycero-3-phosphocholine analog has a Doxyl PC, a spin probe attached to it covalently.
Anwendung
16:0-5 Doxyl PC may be used:
- as a component in virus-like large unilamellar vesicles (VL LUVs) to quench 4-chloro-7-nitrobenz-2-oxa-1,3-diazole (NBD) fluorescence emission
- in the preparation of multi-lamellar vesicles (MLVs) as a site-specific quencher to perform fluorescence quenching studies
- in the preparation of spin-labelled multi-lamellar vesicles (MLVs)
Biochem./physiol. Wirkung
Phosphatidylcholine (PC) lowers the levels of cholesterol and triglycerides.
Verpackung
5 mL Clear Glass Sealed Ampule (810601P-1mg)
Angaben zur Herstellung
Product use: To prevent aggregation, prepare water-based solutions of 2 mM stock solutions of n-DOXYL PCs and store in plastic. Dilute stock solutions to 0.03- 0.1 mM solutions for EPR studies. For liposome preparations in fluorescent quenching measurements, dissolve the doxyl lipid in 150 μl absolute ethanol for a concentration of 40.3 mM , Additional supplemental information.
Rechtliche Hinweise
Avanti Research is a trademark of Avanti Polar Lipids, LLC
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Lagerklassenschlüssel
11 - Combustible Solids
Analysenzertifikate (COA)
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The distribution of the lipid-attached doxyl electron paramagnetic resonance (EPR) spin label in 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine membranes has been studied by (1)H and (13)C magic angle spinning nuclear magnetic resonance relaxation measurements. The doxyl spin label was covalently attached to the 5th
Diego E Sastre et al.
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McConnell HM
Advances in Protein Chemistry, 49, 135-148 (1996)
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