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800725P
Avanti
N-P Tyrosine PA
Avanti Research™ - A Croda Brand 800725P, powder
Synonym(e):
N-palmitoyl-tyrosine phosphoric acid (ammonium salt)
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About This Item
Empfohlene Produkte
Assay
>99% (TLC)
Form
powder
Verpackung
pkg of 1 × 1 mg (800725P-1mg)
Hersteller/Markenname
Avanti Research™ - A Croda Brand 800725P
Lipid-Typ
phospholipids
cardiolipins
Versandbedingung
dry ice
Lagertemp.
−20°C
Allgemeine Beschreibung
Lysophosphatidic acid (LPA) receptor modulators include N-palmitoyl serine phosphoric acid and N-palmitoyl-tyrosine phosphoric acid. N-palmitoyl serine phosphoric acid and N-palmitoyl-tyrosine phosphoric acid are competitive inhibitors of the LPA receptor in Xenopus oocytes. However, in mammalian cells, N-palmitoyl-tyrosine phosphoric acid may act as an agonist for the LPA receptor. LPA is a lipid mediator that acts similar to growth factors through G-protein coupled plasma membrane receptors. LPA may play a role in platelet aggregation, smooth muscle contraction, vasoactive changes, cytoskeletal reorganization and cell proliferation.
Verpackung
5 mL Amber Glass Screw Cap Vial (800725P-1mg)
Angaben zur Herstellung
Product use: N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acid can be used for cell studies. dissolved these lipids in 0.1 mL PBS containing 0.1 mg/mL human serum albumin before adding to cells. In X. laevis studies, these LPA inhibitors were dissolved in DMSO at 1 mM and filtered through a 0.45 mM membrane filter before injection.
Rechtliche Hinweise
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Lagerklassenschlüssel
11 - Combustible Solids
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Hydrolysis of phosphatidylserine-exposing red blood cells by secretory phospholipase A2 generates lysophosphatidic acid and results in vascular dysfunction.
The Journal of Biological Chemistry, 281, 775-781 (2006)
Inhibitors of lipid phosphatidate receptors: N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acids
Journal of Lipid Research, 37, 391-398 (1996)
Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization
Molecular Pharmacology, 54, 881-888 (1998)
Inhibitors of lipid phosphatidate receptors: N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acids
Journal of Lipid Research, 37, 391-398 (1996)
Journal of lipid research, 37(2), 391-398 (1996-02-01)
An improved synthesis of two lipid phosphoric acids, N-palmitoyl-L-serine phosphoric acid (NP-Ser-PA) and N-palmitoyl-L-tyrosine phosphoric acid (NP-Tyr-PA), from the benzyl esters of L-serine and L-tyrosine is described. The sequence of N-acylation, followed by phosphitylation with N, N-diisopropyl dibenzyl phosphoramidite, oxidation
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