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800725P

Avanti

N-P Tyrosine PA

Avanti Research - A Croda Brand 800725P, powder

Synonym(e):

N-palmitoyl-tyrosine phosphoric acid (ammonium salt)

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About This Item

Empirische Formel (Hill-System):
C25H48N3O7P
CAS-Nummer:
Molekulargewicht:
533.64
UNSPSC-Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

Form

powder

Verpackung

pkg of 1 × 1 mg (800725P-1mg)

Hersteller/Markenname

Avanti Research - A Croda Brand 800725P

Lipid-Typ

phospholipids
cardiolipins

Versandbedingung

dry ice

Lagertemp.

−20°C

Allgemeine Beschreibung

Lysophosphatidic acid (LPA) receptor modulators include N-palmitoyl serine phosphoric acid and N-palmitoyl-tyrosine phosphoric acid. N-palmitoyl serine phosphoric acid and N-palmitoyl-tyrosine phosphoric acid are competitive inhibitors of the LPA receptor in Xenopus oocytes. However, in mammalian cells, N-palmitoyl-tyrosine phosphoric acid may act as an agonist for the LPA receptor. LPA is a lipid mediator that acts similar to growth factors through G-protein coupled plasma membrane receptors. LPA may play a role in platelet aggregation, smooth muscle contraction, vasoactive changes, cytoskeletal reorganization and cell proliferation.

Verpackung

5 mL Amber Glass Screw Cap Vial (800725P-1mg)

Angaben zur Herstellung

Product use: N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acid can be used for cell studies. dissolved these lipids in 0.1 mL PBS containing 0.1 mg/mL human serum albumin before adding to cells. In X. laevis studies, these LPA inhibitors were dissolved in DMSO at 1 mM and filtered through a 0.45 mM membrane filter before injection.

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Lagerklassenschlüssel

11 - Combustible Solids


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Hydrolysis of phosphatidylserine-exposing red blood cells by secretory phospholipase A2 generates lysophosphatidic acid and results in vascular dysfunction.
Neidlinger, N.A, et. al.
The Journal of Biological Chemistry, 281, 775-781 (2006)
Inhibitors of lipid phosphatidate receptors: N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acids
Bittman, R, et. al.
Journal of Lipid Research, 37, 391-398 (1996)
Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization
An, S
Molecular Pharmacology, 54, 881-888 (1998)
Inhibitors of lipid phosphatidate receptors: N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acids
Bittman, R
Journal of Lipid Research, 37, 391-398 (1996)
R Bittman et al.
Journal of lipid research, 37(2), 391-398 (1996-02-01)
An improved synthesis of two lipid phosphoric acids, N-palmitoyl-L-serine phosphoric acid (NP-Ser-PA) and N-palmitoyl-L-tyrosine phosphoric acid (NP-Tyr-PA), from the benzyl esters of L-serine and L-tyrosine is described. The sequence of N-acylation, followed by phosphitylation with N, N-diisopropyl dibenzyl phosphoramidite, oxidation

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