934429

3-((4-(Piperidin-4-yl)phenyl)amino)piperidine-2,6-dione hydrochloride

≥95%

• Synonym(e): 3-((4-(Piperidin-4-yl)phenyl)amino)piperidine-2,6-dione hydrochloride
• Empirische Formel (Hill-System): C₁₆H₂₁N₃O₂ · xHCl
• Molekulargewicht: 287.36 (free base basis)
• UNSPSC-Code: 12352200
• NACRES: NA.21

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95%
• Form: powder
• Lagertemp.: 2-8°C
• SMILES String: O=C1NC(C(NC2=CC=C(C=C2)C3CCNCC3)CC1)=O.[xHCl]

Beschreibung

Anwendung

A functionalized cereblon ligand for development of Thalidomide based PROTACs. Allows rapid conjugation with carboxyl linkers due to presence of amine group via peptide coupling reactions. Amenable for linker attachement via reductive amination, and a basic building block for making protein degrader library.

Technology Spotlight:

Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

Sonstige Hinweise

Targeted Protein Degradation by Small Molecules
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs

Rechtliche Hinweise

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable