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Wichtige Dokumente
930687
2,6-Piperidinedione, 3-[(3-aminophenyl)amino] hydrochloride
≥95%
Synonym(e):
3-((3-Aminophenyl)amino)piperidine-2,6-dione hydrochloride
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About This Item
Empirische Formel (Hill-System):
C11H13N3O2 · xHCl
CAS-Nummer:
Molekulargewicht:
219.24 (free base basis)
MDL-Nummer:
UNSPSC-Code:
12352200
NACRES:
NA.28
Empfohlene Produkte
Qualitätsniveau
Assay
≥95%
Eignung der Reaktion
reagent type: ligand
Funktionelle Gruppe
amine
Lagertemp.
2-8°C
SMILES String
O=C1NC(C(CC1)NC2=CC(N)=CC=C2)=O.[xHCl]
Anwendung
2,6-Piperidinedione, 3-[(3-aminophenyl)amino] hydrochloride is a functionalized Cereblon ligand used for development of protein degrader building blocks. Contains a terminal amine group, allowing rapid conjugation of carboxyl containing linkers. A basic building block for development of a protein degrader library.
Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks
Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks
Sonstige Hinweise
Targeted Protein Degradation by Small Molecules
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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Analysenzertifikate (COA)
Lot/Batch Number
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Daniel P Bondeson et al.
Annual review of pharmacology and toxicology, 57, 107-123 (2016-10-13)
Protein homeostasis networks are highly regulated systems responsible for maintaining the health and productivity of cells. Whereas therapeutics have been developed to disrupt protein homeostasis, more recently identified techniques have been used to repurpose homeostatic networks to effect degradation of
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