930520

Pomalidomide-PEG₂-C₂-NH₂ hydrochloride

≥95%

• Synonym(e): 1H-Isoindole-1,3(2H)-dione, 4-[[2-[2-(2-aminoethoxy)ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl), 4-[[2-[2-(2-Aminoethoxy)ethoxy]ethyl]amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
• Empirische Formel (Hill-System): C₁₉H₂₄N₄O₆ · xHCl
• CAS-Nummer: 2245697-87-2
• Molekulargewicht: 404.42 (free base basis)
• MDL-Nummer: MFCD32263424

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95%
• Form: powder
• Funktionelle Gruppe: amine
• Lagertemp.: 2-8°C
• SMILES String: O=C1NC(C(CC1)N2C(C3=C(C2=O)C(NCCOCCOCCN)=CC=C3)=O)=O

Beschreibung

Anwendung

Pomalidomide-PEG₂-C₂-NH₂ hydrochloride is a functionalized cereblon ligand for development of pomalidomide-based PROTACs. Allows rapid conjugation with carboxyl linkers due to the presence of an amine group via peptide coupling reactions. It is also active for linker attachment via reductive amination, and a basic building block for development of a protein degrader library.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

Sonstige Hinweise

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable