920908

(S,R,S)-VL285 Phenol

• Synonym(e): (2S,4R)-4-Hydroxy-N-(2-hydroxy-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)pyrrolidine-2-carboxamide, VHL E3 ligase ligand for PROTAC^® research
• Empirische Formel (Hill-System): C₂₉H₃₂N₄O₅S
• CAS-Nummer: 1448188-69-9
• Molekulargewicht: 548.65
• MDL-Nummer: MFCD31746640
• UNSPSC-Code: 12352200
• NACRES: NA.22

Eigenschaften

• ligand: VL285 phenol
• Qualitätsniveau: 100
• Form: solid
• Eignung der Reaktion: reagent type: ligand
• Funktionelle Gruppe: amine
• Lagertemp.: 2-8°C
• SMILES String: O=C([C@@H]1C[C@@H](O)CN1C([C@H](C(C)C)N2CC(C=CC=C3)=C3C2=O)=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4O
• InChI: 1S/C29H32N4O5S/c1-16(2)25(33-13-20-6-4-5-7-22(20)28(33)37)29(38)32-14-21(34)11-23(32)27(36)30-12-19-9-8-18(10-24(19)35)26-17(3)31-15-39-26/h4-10,15-16,21,23,25,34-35H,11-14H2,1-3H3,(H,30,36)/t21-,23+,25+/m1/s1
• InChIKey: KNZQRBRUYSXXRG-VTZPFEBOSA-N

Beschreibung

Anwendung

(S,R,S)-VL285 Phenol is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology, providing an alternative to the widely used VH032 (901490).

(S,R,S)-VL285 Phenol-linker conjugates are also available for synthesis of degraders. Browse our full offering of degrader building blocks that streamlines the synthesis of degrader libraries.

Sonstige Hinweise

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins

Systematic exploration of different E3 ubiquitin ligases: an approach towards potent and selective CDK6 degraders

Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties

Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase

Rechtliche Hinweise

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable