861650

(+)-Biotin-4-nitrophenylester

98%

• Synonym(e): 4-Nitrophenyl-(+)-biotinat, d-Biotin-p-nitrophenyl-ester, BNP
• Empirische Formel (Hill-System): C₁₆H₁₉N₃O₅S
• CAS-Nummer: 33755-53-2
• Molekulargewicht: 365.40
• Beilstein: 5795805
• MDL-Nummer: MFCD15141972
• UNSPSC-Code: 12352108
• PubChem Substanz-ID: 24888552
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 200
• Assay: 98%
• Form: powder
• Optische Aktivität: [α]25/D +51°, c = 2 in DMF: AcOH (99:1)
• mp (Schmelzpunkt): 163-165 °C (lit.)
• Löslichkeit: methanol: 25 mg/mL, clear, colorless to greenish-yellow
• SMILES String: [O-][N+](=O)c1ccc(OC(=O)CCCC[C@@H]2SCC3NC(=O)NC23)cc1
• InChI: 1S/C16H19N3O5S/c20-14(24-11-7-5-10(6-8-11)19(22)23)4-2-1-3-13-15-12(9-25-13)17-16(21)18-15/h5-8,12-13,15H,1-4,9H2,(H2,17,18,21)/t12-,13-,15-/m0/s1
• InChIKey: YUDNXDTXQPYKCA-YDHLFZDLSA-N

Beschreibung

Anwendung

(+)-Biotin 4-nitrophenyl ester may be used in the preparation of biotin tagged ARC (adenosine-oligoarginine conjugate) derivative during cellular protein uptake studies. It may also be used to prepare biotinylated quinazoline derivatives, which shows inhibitory activities against VEGFR-2 (vascular endothelial growth factor receptor-2) tyrosine kinase. (+)-Biotin 4-nitrophenyl ester undergoes hydrolysis in the presence of Na[¹⁷O]H to form [¹⁷O₂]biotin, which can be used in solid-state ¹⁷O NMR spectroscopic experiments to analyze large protein-ligand complexes.

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Verpackung

Bottomless glass bottle. Contents are inside inserted fused cone.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)