79625

Phosphorsäure-dichlorid-dimethylamid

≥98.0% (AT)

• Synonym(e): (Dimethylamido)-phosphorsäuredichlorid, N,N-Dimethylphosphoramidsäure-dichlorid
• Lineare Formel: (CH₃)₂NP(O)Cl₂
• CAS-Nummer: 677-43-0
• Molekulargewicht: 161.95
• Beilstein: 969956
• EG-Nummer: 211-641-2
• MDL-Nummer: MFCD00013896
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 57652812
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98.0% (AT)
• Form: liquid
• Brechungsindex: n20/D 1.464
• bp: 77-79 °C/11 mmHg (lit.)
• Dichte: 1.362 g/mL at 20 °C (lit.)
• Funktionelle Gruppe: phosphoramide
• Lagertemp.: 2-8°C
• SMILES String: CN(C)P(Cl)(Cl)=O
• InChI: 1S/C2H6Cl2NOP/c1-5(2)7(3,4)6/h1-2H3
• InChIKey: YNHXBEVSSILHPI-UHFFFAOYSA-N

Beschreibung

Anwendung

N,N-Dimethylphosphoramic dichloride can be used as a reagent:

• For the activation of carboxylic acids.
• To prepare functionalized β-lactams by reacting with acetic acids and imines.
• To synthesize phosphoramidic esters by reacting with alcohols in the presence of a base catalyst.
• To prepare [1,2,4]triazolo[4,3-c][1,3,5,2]triazaphosphinine-5-oxide derivatives by reacting with N-alkyl/aryl-N′-(4H-1,2,4-triazol-3-yl) amidines in the presence of triethylamine.

Sicherheitshinweise

• Piktogramme: GHS05
• Signalwort: Danger
• H-Sätze: H314
• P-Sätze: P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363 - P405
• Gefahreneinstufungen: Skin Corr. 1B
• Lagerklassenschlüssel: 8A - Combustible corrosive hazardous materials
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter