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O,O′-Bis-[2-(N-succinimidyl-succinylamino)-ethyl]-polyethylenglykol

2,000

Synonym(e):

α,ω-Bis-NHS-PEG, Di-(N-succinimidyl)-PEG-disäure, PEG-bis-(N-succinimidyl-succinat)

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About This Item

CAS-Nummer:
186020-53-1
MDL-Nummer:
MFCD03792507
UNSPSC-Code:
12162002
NACRES:
NA.22

Qualitätsniveau

100

Form

powder

Mol-Gew.

average Mn 2,000

Eignung der Reaktion

reagent type: cross-linking reagent

Ω-Ende

NHS ester

α-Ende

NHS ester

Lagertemp.

−20°C

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Allgemeine Beschreibung

O,O′-Bis[2-(N-Succinimidyl-succinylamino)ethyl]polyethylene glycol (NHS-PEG-NHS) is a cross-linking reagent.

Anwendung

O,O′-Bis[2-(N-Succinimidyl-succinylamino)ethyl]polyethylene glycol (NHS-PEG-NHS) is suitable reagent used in the covalent conjugation of peanut agglutinin and anticarcinoembryonic antigen antibodies (αCEA) tumor-targeting ligands to near-infrared (NIR)fluorescent superparamagnetic iron oxide (IO)- human serum albumin (HSA) nanoparticles. It is suitable reagent used in the synthesis of novel series of mesoporous silica nanoparticles with different pore sizes, useful for high loading and controlled release of short oligonucleotides.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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Jixi Zhang et al.
Dalton transactions (Cambridge, England : 2003), 43(10), 4115-4126 (2014-01-25)
Aimed at high loading and controlled release of oligonucleotides with short sequences of base-pairs, a novel series of mesoporous silica nanoparticles with three different pore sizes (3.5-5.0 nm) but the same cleavable surface linkers (MSN-Linker-Cys) were synthesized. The small particle
Enav Corem-Salkmon et al.
International journal of nanomedicine, 7, 5517-5527 (2012-11-01)
Colon cancer is one of the major causes of death in the Western world. Early detection significantly improves long-term survival for patients with the disease. Near- infrared (NIR) fluorescent nanoparticles hold great promise as contrast agents for tumor detection. NIR

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