702757

Kalium-tert-pentoxid -Lösung

2 M in THF

• Synonym(e): Kalium-(2-methyl-2-butanolat), Kalium-tert.-pentylat -Lösung
• Lineare Formel: CH₃CH₂C(CH₃)₂OK
• CAS-Nummer: 41233-93-6
• Molekulargewicht: 126.24
• Beilstein: 4149025
• MDL-Nummer: MFCD00064808
• UNSPSC-Code: 12352001
• PubChem Substanz-ID: 329762401
• NACRES: NA.22

Eigenschaften

• Form: liquid
• Konzentration: 2 M in THF
• Dichte: 0.920 g/mL at 25 °C
• SMILES String: [K+].CCC(C)(C)[O-]
• InChI: 1S/C5H11O.K/c1-4-5(2,3)6;/h4H2,1-3H3;/q-1;+1
• InChIKey: ZRLVQFQTCMUIRM-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Potassiumtert-pentoxide solution is a strong and sterically hindered alkoxide baseprepared by treating oil-free potassium hydride with anhydrous t-pentylalcohol in anhydrous solvent.

Anwendung

Potassium tert-pentoxide solution can be used as a base in the:

• Wittig reaction of ketoesters with methyltriphenylphosphonium bromide to synthesize alkenes.
• Palladium-catalyzed Buchwald-Hartwig amination reaction.

It can also be used:

• To prepare potassium tert-pentoxide-crown ether complexes, which is used as a Lewis base catalyst in Mukaiyama aldol reaction.
• As an activator for (difluoromethyl)trimethylsilane to generate difluoromethyl-carbanion which reacts with isothiocyanate to synthesize α, α-difluoromethyl thioamide.

Leistungsmerkmale und Vorteile

In the absence of air and moisture, potassium tert-pentoxide solutions in benzene or toluene may be stored in a refrigerator for up to 1 year without significant deterioration.

Sicherheitshinweise

• Piktogramme: GHS02,GHS08,GHS05,GHS07
• Signalwort: Danger
• H-Sätze: H225,H302,H314,H335,H336,H351
• P-Sätze: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - STOT SE 3
• Zielorgane: Central nervous system, Respiratory system
• Zusätzliche Gefahrenhinweise: EUH019
• Lagerklassenschlüssel: 3 - Flammable liquids
• WGK: WGK 3
• Flammpunkt (°F): 1.4 °F - Solvent
• Flammpunkt (°C): -17 °C - Solvent
• Persönliche Schutzausrüstung: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter