653233

2,4-Dichlor-5-Fluorpyrimidin

97%

• Empirische Formel (Hill-System): C₄HCl₂FN₂
• CAS-Nummer: 2927-71-1
• Molekulargewicht: 166.97
• MDL-Nummer: MFCD00233551
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 24883938
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 100
• Assay: 97%
• Form: solid
• mp (Schmelzpunkt): 37-41 °C (lit.)
• Funktionelle Gruppe: chloro; fluoro
• SMILES String: Fc1cnc(Cl)nc1Cl
• InChI: 1S/C4HCl2FN2/c5-3-2(7)1-8-4(6)9-3/h1H
• InChIKey: WHPFEQUEHBULBW-UHFFFAOYSA-N

Beschreibung

Anwendung

2,4-Dichloro-5-fluoropyrimidine can be used as a starting material to synthesize:

• 5-fluoropyrimidine-2-carboxamides and 5-fluoropyrimidine-4-carboxamides as potential kinase inhibitors.
• A series of 2,4-diamino-5-fluoropyrimidine derivatives as potential protein kinase Cθ inhibitors.
• 2,4-Bisanilinopyrimidine derivatives as potential aurora kinases inhibitors.
• 5-fluoro-N,N-bis(4-methoxyphenyl)-2,4-pyrimidinediamine by reacting with p-methoxy aniline in the presence of DIPEA.
• 2-chloro-5-fluoro-4-(4-fluorophenyl)pyrimidine by Suzuki coupling reaction in the presence of (4-fluorophenyl)boronic acid triphenylphosphine, and palladium(II) acetate catalyst.
• 5-fluoro-2-(piperidin-4-yloxy)pyrimidin-4-amine, a scaffold, which is used in the preparation of potent deoxycytidine kinase inhibitors.

Sicherheitshinweise

• Piktogramme: GHS05,GHS07
• Signalwort: Danger
• H-Sätze: H302,H314,H317
• P-Sätze: P260 - P272 - P280 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1A
• Lagerklassenschlüssel: 8A - Combustible corrosive hazardous materials
• WGK: WGK 3
• Flammpunkt (°F): 222.8 °F - closed cup
• Flammpunkt (°C): 106 °C - closed cup
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges