638099

CyJohnPhos

97%

• Synonym(e): (2-Biphenylyl)-dicyclohexylphosphin, (2-Biphenyl)-dicyclohexylphosphin, Cyclohexyl-JohnPhos
• Empirische Formel (Hill-System): C₂₄H₃₁P
• CAS-Nummer: 247940-06-3
• Molekulargewicht: 350.48
• Beilstein: 8440533
• MDL-Nummer: MFCD01862441
• UNSPSC-Code: 12352002
• PubChem Substanz-ID: 24882909
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 100
• Assay: 97%
• Eignung der Reaktion: reaction type: Cross Couplings; reagent type: ligand; reaction type: Arylations; reagent type: ligand; reaction type: Buchwald-Hartwig Cross Coupling Reaction; reagent type: ligand; reaction type: C-X Bond Formation; reagent type: ligand; reaction type: Hiyama Coupling; reagent type: ligand; reaction type: Methylations; reagent type: ligand; reaction type: Negishi Coupling; reagent type: ligand; reaction type: Oxidations; reagent type: ligand; reaction type: Suzuki-Miyaura Coupling
• mp (Schmelzpunkt): 102-106 °C (lit.)
• Funktionelle Gruppe: phosphine
• SMILES String: C1CCC(CC1)P(C2CCCCC2)c3ccccc3-c4ccccc4
• InChI: 1S/C24H31P/c1-4-12-20(13-5-1)23-18-10-11-19-24(23)25(21-14-6-2-7-15-21)22-16-8-3-9-17-22/h1,4-5,10-13,18-19,21-22H,2-3,6-9,14-17H2
• InChIKey: LCSNDSFWVKMJCT-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

CyJohnPhos [(2-Biphenyl)dicyclohexylphosphine] is an air-stable, bulky and electron-rich monodentate biarylphosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions.

Learn more about Buchwald Phosphine Ligands

Anwendung

Ligand employed in the palladium-catalysed synthesis of 1,3,5-tris(2′-aminophenyl)benzene, a core building block for potential ionic receptors.

CyJohnPhos may be used in combination with a nickel catalyst for the Suzuki-Miyaura arylation of tertiary benzylic acetates with aryl boroxines to produce diaryl and triaryl quaternary stereocenters.

Ligand for amination of aryl halides and triflates.

Rechtliche Hinweise

Anwendung unterliegt US Patente 6307087 und 6395916.

Sicherheitshinweise

• H-Sätze: H413
• Gefahreneinstufungen: Aquatic Chronic 4
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)