249505

2,6-Di-tert.-butyl-4-methyl-pyridin

98%

• Synonym(e): 2,6-Bis(1,1-dimethylethyl)-4-methylpyridine, 2,6-Bis(tert-butyl)-4-methylpyridine, 2,6-Ditert-butyl-4-methylpyridine, 4-Methyl-2,6-di-tert-butylpyridine
• Empirische Formel (Hill-System): C₁₄H₂₃N
• CAS-Nummer: 38222-83-2
• Molekulargewicht: 205.34
• Beilstein: 130503
• EG-Nummer: 253-834-4
• MDL-Nummer: MFCD00006305
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 24855001
• NACRES: NA.22

Eigenschaften

• Assay: 98%
• Form: solid
• Brechungsindex: n20/D 1.4763 (lit.)
• bp: 233 °C (lit.)
• mp (Schmelzpunkt): 33-36 °C (lit.)
• Löslichkeit: ethanol: soluble 5%, clear to slightly hazy, colorless to dark yellow
• Lagertemp.: 2-8°C
• SMILES String: Cc1cc(nc(c1)C(C)(C)C)C(C)(C)C
• InChI: 1S/C14H23N/c1-10-8-11(13(2,3)4)15-12(9-10)14(5,6)7/h8-9H,1-7H3
• InChIKey: HVHZEKKZMFRULH-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

2,6-Di-tert-butyl-4-methylpyridine is a sterically hindered, non-nucleophilic base which distinguishes between BrÖnsted (protonic) and Lewis acids. It also enables the direct high-yield conversion of aldehydes and ketones to vinyl triflates. It inhibits desilylation and hydration of the products during GaCl₃-catalyzed ortho-ethynylation of phenol.

Anwendung

2,6-Di-tert-butyl-4-methylpyridine has been used:

• in the synthesis of 1,2-dihydro-2-silanaphthalene derivatives
• as base in PtCl₄-catalyzed cyclization reactions of homopropargyl azide derivatives
• diastereoselective synthesis of β-thiomannopyranosides

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302,H315,H319,H335
• P-Sätze: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): 183.2 °F - closed cup
• Flammpunkt (°C): 84 °C - closed cup
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves