222429

5-Methylisatin

95%

• Synonym(e): 5-Methylindolin-2,3-dion
• Empirische Formel (Hill-System): C₉H₇NO₂
• CAS-Nummer: 608-05-9
• Molekulargewicht: 161.16
• EG-Nummer: 210-152-1
• MDL-Nummer: MFCD00005721
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 24853331
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 100
• Assay: 95%
• Form: solid
• mp (Schmelzpunkt): 180 °C (dec.) (lit.)
• Löslichkeit: methanol: soluble 25 mg/mL, clear to slightly hazy, orange to red
• SMILES String: Cc1ccc2NC(=O)C(=O)c2c1
• InChI: 1S/C9H7NO2/c1-5-2-3-7-6(4-5)8(11)9(12)10-7/h2-4H,1H3,(H,10,11,12)
• InChIKey: VAJCSPZKMVQIAP-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

5-Methylisatin is an inhibitor of atrial natriuretic peptide (ANP) receptor coupled with guanylyl cyclase (GC).

Anwendung

5-Methylisatin was used as an internal standard during the determination of isatin (indole-2, 3-
dione) in body fluids by capillary column gas chromatography-mass spectrometry (GC—MS).

Reactant for preparation of:

• Antimycobacterial agents
• Promoters of central nervous system (CNS) depression in mice
• Inhibitors of TAK1 kinase
• Anti-human immunodeficiency virus (HIV) agent
• Potent herpes simplex virus (HSV) inhibitors
• Antimicrobial agents
• IKKβ inhibitors
• Potential drug to combat human immunodeficiency virus-tuberculosis (HIV-TB) coinfection
• Cyclooxygenase 1/2 (COX-1/2) and 5-lipoxygenase (5-LOX) inhibitors
• Antibacterial and anticancer agents

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)