Dichloromethane activation. Direct methylenation of ketones and aldehydes with CH2Cl2 promoted by Mg/TiCl4/THF.

Dichloromethane activation. Direct methylenation of ketones and aldehydes with CH2Cl2 promoted by Mg/TiCl4/THF.

Organic letters (2004-12-21)

Tu-Hsin Yan, Chia-Chung Tsai, Ching-Ting Chien, Chia-Ching Cho, Pei-Chen Huang

ABSTRACT

[reaction: see text] This Mg-TiCl4-promoted CH2-transfer reaction of CH2Cl2 represents an extremely simple, practical, and efficient methylenation of a variety of ketones and aldehydes, especially in enolizable or sterically hindered ketones such as 2,2-dimethylcyclohexanone, camphor, and fenchone.

MATERIALI

N° Catalogo

Marchio

Descrizione del prodotto

373613

Sigma-Aldrich

2,2-Dimethylcyclohexanone, 92%