V900351
5-Fluorocytosine
Vetec™, reagent grade, 99%
Sinonimo/i:
4-amino-5-fluoro-2(1H)-pyrimidinone, Flucytosine
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About This Item
Formula empirica (notazione di Hill):
C4H4FN3O
Numero CAS:
Peso molecolare:
129.09
Beilstein:
127285
Numero CE:
Numero MDL:
Codice UNSPSC:
41116107
ID PubChem:
Grado
reagent grade
Nome Commerciale
Vetec™
Saggio
99%
Punto di fusione
298-300 °C (dec.) (lit.)
Temperatura di conservazione
2-8°C
Stringa SMILE
NC1=NC(=O)NC=C1F
InChI
1S/C4H4FN3O/c5-2-1-7-4(9)8-3(2)6/h1H,(H3,6,7,8,9)
XRECTZIEBJDKEO-UHFFFAOYSA-N
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Azioni biochim/fisiol
Nucleoside analog that has antifungal activities. 5-FC is deaminated by cytosine deaminase to product 5-fluorouracil, resulting in RNA miscoding. 5-Fluorocytosine inhibits DNA and RNA synthesis and interferes with ribosomal protein synthesis.
Note legali
Vetec is a trademark of Merck KGaA, Darmstadt, Germany
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In our previous works, we demonstrated that human neural stem cells (NSCs) transduced with the cytosine deaminase (CD) gene showed remarkable 'bystander killer effect' on glioma and medulloblastoma cells after administration of the prodrug 5-fluorocytosine (5-FC). In addition, herpes simplex
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To investigate whether hypoxia targeted bifunctional suicide gene expression-cytosine deaminase (CD) and uracil phosphoribosyltransferase (UPRT) with 5-FC treatments can enhance radiotherapy. Stable transfectants of R3327-AT cells were established which express a triple-fusion-gene: CD, UPRT and monomoric DsRed (mDsRed) controlled by
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