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Z4527

Sigma-Aldrich

Zopolrestat

≥98% (HPLC)

Sinonimo/i:

3,4-Dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl]methyl]-1-phthalazineacetic acid, Alond, CP-73850, Xedia

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About This Item

Formula empirica (notazione di Hill):
C19H12F3N3O3S
Numero CAS:
110703-94-1
Peso molecolare:
419.38
Numero MDL:
MFCD00865476
Codice UNSPSC:
12352200
ID PubChem:
329831615
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Stato

powder

Colore

off-white to light brown

Solubilità

DMSO: ≥20 mg/mL

Temperatura di conservazione

2-8°C

Stringa SMILE

OC(=O)CC1=NN(Cc2nc3cc(ccc3s2)C(F)(F)F)C(=O)c4ccccc14

InChI

1S/C19H12F3N3O3S/c20-19(21,22)10-5-6-15-14(7-10)23-16(29-15)9-25-18(28)12-4-2-1-3-11(12)13(24-25)8-17(26)27/h1-7H,8-9H2,(H,26,27)
BCSVCWVQNOXFGL-UHFFFAOYSA-N

Categorie correlate

Azioni biochim/fisiol

Zopolrestat is an inhibitor of Aldose Reductase.
Zopolrestat is an inhibitor of Aldose Reductase. AR family members AKR1B1 and AKR1B10 have additionally been shown to play roles in inflammation and cancer.

Caratteristiche e vantaggi

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H301,H413

Classi di pericolo

Acute Tox. 3 Oral - Aquatic Chronic 4

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
017M4752V
090M4628V
090M4628

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Cornelia Koch et al.
Biochimica et biophysica acta, 1810(9), 879-887 (2011-06-21)
Flexibility is a common feature of proteins. For human aldose reductase, a variety of conformers have been observed in crystalline complexes with different inhibitors. A study of crystal structures and isothermal titration calorimetry was performed on wild type and mutated
Liping Zou et al.
International journal of molecular medicine, 30(2), 409-416 (2012-05-23)
Aldose reductase (AR), the first and the rate-limiting enzyme of the polyol pathway, has been implicated in platelet-derived growth factor (PDGF)-induced proliferation of rat mesangial cells (MsCs). It is well known that AR plays an important role in various chronic
Wai Ho Tang et al.
Journal of molecular and cellular cardiology, 49(1), 58-69 (2009-12-23)
A number of studies have shown that the polyol pathway, consisting of aldose reductase (AR) and sorbitol dehydrogenase (SDH), contributes to ischemia-reperfusion (I/R)-induced myocardial infarction due to depletion of ATP. In this report we show that the polyol pathway in
Tao Jiang et al.
Zhonghua bing li xue za zhi = Chinese journal of pathology, 34(3), 171-174 (2005-06-09)
To study the effect of aldose reductase (AR) on expression of fibronectin and collagen IV in cultured rat renal mesangial cells (MsC). AR expression plasmid vector (pCDNA3-AR) was constructed by restriction endonuclease digestion and ligation procedures. Stable expression of AR
Yu-Jung Chen et al.
American journal of physiology. Heart and circulatory physiology, 294(5), H2305-H2312 (2008-03-11)
We confirmed that release of 20-hydroxyeicosatetraenoic acid (20-HETE) from the isolated perfused kidney of diabetic rats is greatly reduced compared with age-matched control rats. The present studies were undertaken to examine potential mechanisms for the deficit in renal 20-HETE in
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